Morphological change and cellular differentiation induced by cisplatin in human neuroblastoma cell lines

Maria Teresa Parodi, Luigi Varesio, Gian Paolo Tonini

Research output: Contribution to journalArticle

Abstract

In 1986 we reported on the capacity of cis-diamminedichloroplatinum(II) (cisplatin, CDDP) to induce erythroid cellular differentiation in the K562 cell [9]. To continue our study of the differentiating activity of cisplatin, we treated two human neuroblastoma cell lines with different doses of the drug in vitro. Both cell lines showed changes in morphology; however, only one achieved a fully differentiated neuronal phenotype (cisplatin concentration 1 μg/ml). The differentiated neuroblastoma cells exhibited extensive neurite outgrowth that reached maximal elongation after 5 days of culture, forming several interconnections. Cisplatin could induce neuronal differentiation, as did retinoic acid, a neuroblastoma-differentiating agent. The results show that cisplatin should be a candidate for further in vitro and in vivo studies of induced differentiation.

Original languageEnglish
Pages (from-to)114-116
Number of pages3
JournalCancer Chemotherapy and Pharmacology
Volume25
Issue number2
DOIs
Publication statusPublished - Mar 1989

ASJC Scopus subject areas

  • Pharmacology
  • Oncology
  • Cancer Research

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