Morphological changes in growth-plate cartilage in osteogenesis imperfecta

C. Sanguinetti, F. Greco, L. De Palma, N. Specchia, F. Falciglia

Research output: Contribution to journalArticlepeer-review


We obtained specimens of growth-plate cartilage from four patients with osteogenesis imperfecta. Light microscopy showed structural changes in the tissue and morphological changes in chondrocytes and matrix, particularly in the hypertrophic zone. There were changes in the process of calcification in the primary mineralisation zone of the cartilage. We also found histochemical changes in the matrix glycosaminoglycans (GAGs) in the zones where physiological mineralisation was disturbed and where the trabeculae were interrupted and poorly mineralised. In addition to the known molecular defects in collagen, changes in GAGs and non-collagenous proteins are important factors in the pathogenesis of the disease.

Original languageEnglish
Pages (from-to)475-479
Number of pages5
JournalJournal of Bone and Joint Surgery - Series B
Issue number3
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery


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