Morphological changes of bladder mucosa in patients who underwent instillation with combined sodium hyaluronic acid-chondroitin sulphate (ialuril®)

E. Costantini, M. Lazzeri, D. Pistolesi, M. Del Zingaro, E. Frumenzio, A. Boni, A. Pietropaolo, E. Fragalà, M. Porena

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To investigate what changes are endoscopically evident after glycosaminoglycans (GAGs) therapy by hyaluronic acid (HA) and chondroitin sulphate (CS) (Ialuril®) in female patients affected by bladder pain syndrome(BPS)/ interstitial cystitis (IC) or recurrent urinary tract infections (rUTIs). Patients and Methods: 21 female patients over 18 years affected by rUTIs or BPS/IC received intravesical instillation of HA and CS (4 weekly instillations followed by 2 instillations every 2 weeks and 2 instillation monthly). Post-treatment evaluation included cystoscopy and patient assessment of improvement in symptoms and satisfaction on a visual analogue scale (VAS) from 0 to 10. Results: The post-treatment endoscopy showed a positive effect on bladder mucosa morphology. In 2 cases, treatment did not change endoscopic findings and clinical symptoms. In the other patients, when macroscopic features of the bladder mucosa normalized, the clinical picture improved. Conclusions: GAGs therapy by HA and CS (Ialuril) improves the morphology of bladder mucosa in patients with rUTI or BPS/IC.

Original languageEnglish
Pages (from-to)81-88
Number of pages8
JournalUrologia Internationalis
Volume91
Issue number1
DOIs
Publication statusPublished - Jul 2013

Keywords

  • Bladder pain syndrome/interstitial cystitis
  • Chondroitin sulphate
  • Cystoscopy
  • Hyaluronic acid
  • Recurrent urinary tract infections

ASJC Scopus subject areas

  • Urology

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