Morphological damage induced in vivo by lonidamine on human metastatic cancer cells

C. De Martino, T. Battelli, R. Cavaliere, C. Gallo Curcio, M. Bellocci, D. Manocchi, L. Giustini, R. Mattioli, M. Rinaldi, F. Di Filippo

Research output: Contribution to journalArticle

Abstract

Lonidamine was given to several patients affected with different types of neoplasias growing as metastases both in ascites and pleural effusion, and solid cutaneous metastases. The patients with tumor cells in ascites and pleural effusion were treated with Lonidamine per os or in loco injections. In cutaneous metastases. Lonidamine was administered by different routes: (1) per os; (2) local endoarterial: and (3) in association with hyperthermic perfusion with or without antiblastic drugs.

Original languageEnglish
Pages (from-to)94-103
Number of pages10
JournalOncology
Volume41
DOIs
Publication statusPublished - 1984

Keywords

  • Human metastatic cancer cells
  • Local hyperthermia
  • Local injections or infusions
  • Lonidamine
  • Morphological damage
  • Oral treatment

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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