Morphological effects in the mouse myocardium after methylenedioxymethamphetamine administration combined with loud noise exposure

Marco Gesi, Paola Lenzi, Paola Soldani, Michela Ferrucci, Alberto Giusiani, Francesco Fornai, Antonio Paparelli

Research output: Contribution to journalArticle

Abstract

Early toxicity occurring during or immediately after 3,4-methylenedioxymethamphetamine (MDMA, or "ecstasy") administration has not been investigated in detail, although in humans it is responsible for marked side effects, and even death. Acute toxicity induced by MDMA produces rhabdomyolysis involving the myocardium (myocytolysis). Cardiac symptoms, such as tachycardia, hypertension, and arrhythmia, are present to a variable extent in humans abusing ecstasy. In most cases, this substance is abused in the presence of loud noise, which may affect the myocardium. Despite the frequency of the concomitant exposure to ecstasy and loud noise, and the similarities between the early side effects of these two agents, to our knowledge no study has investigated the role of loud noise in modulating MDMA toxicity. Therefore, in the present study, we evaluated whether cardiac effects of MDMA administration following a typical "binging" pattern are enhanced by concomitant exposure to loud noise. We selected low doses of MDMA in order to avoid gross morphological alterations, or lesions detectable under light microscopy. The myocardial alterations observed were visible only at the ultrastructural level. We found a dramatic enhancement of alterations in the mouse heart upon MDMA administration during loud noise exposure. Remarkably, this enhancement was evident both as a decrease in the threshold dose of MDMA necessary to alter the myocardial ultrastructure, and as an increase in myocardial alterations produced by a higher dose of MDMA.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
JournalAnatomical Record
Volume267
Issue number1
DOIs
Publication statusPublished - May 1 2002

Keywords

  • Amphetamines
  • Drugs of abuse
  • Ecstasy
  • Heart
  • MDMA

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Anatomy

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