Morphological identification of alpha-1-antitrypsin in the human small intestine

K. Geboes, M. B. Ray, P. Rutgeerts, F. Callea, V. J. Desmet, G. Vantrappen

Research output: Contribution to journalArticlepeer-review


Alpha-I-antitrypsin immunorectivity was demonstrated by immunofluorescence in epithelial cells of the normal human small intestine. Its presence was also confirmed in biopsies of patients with Crohn's disease. Specific fluorescence was observed in only four out of 14 adult patients with coeliac disease. These results implicate the human small intestinal epithelium as a possible source of alpha-I-antitrypsin. The absence of positive cells may have implications in the aetiology of coeliac disease.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
Issue number1
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology


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