Abstract
Expanders coated with N-carboxybutyl chitosan were inserted into surgical wounds in the dorsal skin of rabbits and the formation of capsular tissue was studied by scanning electron microscopy and transmission electron microscopy. N-carboxybutyl chitosan, in the course of the capsular organization, favours and potentiates the correct proliferation and organization of the tissue, rather than sustaining reactive processes leading to scar formation. N-carboxybutyl chitosan stimulates physiologically the tissue repair process and favours angiogenesis, whilst depressing fibrogenesis to a certain extent. Applications are envisaged in the treatment of wounds and in plastic surgery.
| Original language | English |
|---|---|
| Pages (from-to) | 287-291 |
| Number of pages | 5 |
| Journal | Biomaterials |
| Volume | 12 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1991 |
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Keywords
- angiogenesis
- Chitosan
- tissue regeneration
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomedical Engineering
Cite this
Morphological study of the capsular organization around tissue expanders coated with N-carboxybutyl chitosan. / Biagini, G.; Pugnaloni, A.; Damadei, A.; Bertani, A.; Belligolli, A.; Bicchiega, V.; Muzzarelli, R.
In: Biomaterials, Vol. 12, No. 3, 1991, p. 287-291.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Morphological study of the capsular organization around tissue expanders coated with N-carboxybutyl chitosan
AU - Biagini, G.
AU - Pugnaloni, A.
AU - Damadei, A.
AU - Bertani, A.
AU - Belligolli, A.
AU - Bicchiega, V.
AU - Muzzarelli, R.
PY - 1991
Y1 - 1991
N2 - Expanders coated with N-carboxybutyl chitosan were inserted into surgical wounds in the dorsal skin of rabbits and the formation of capsular tissue was studied by scanning electron microscopy and transmission electron microscopy. N-carboxybutyl chitosan, in the course of the capsular organization, favours and potentiates the correct proliferation and organization of the tissue, rather than sustaining reactive processes leading to scar formation. N-carboxybutyl chitosan stimulates physiologically the tissue repair process and favours angiogenesis, whilst depressing fibrogenesis to a certain extent. Applications are envisaged in the treatment of wounds and in plastic surgery.
AB - Expanders coated with N-carboxybutyl chitosan were inserted into surgical wounds in the dorsal skin of rabbits and the formation of capsular tissue was studied by scanning electron microscopy and transmission electron microscopy. N-carboxybutyl chitosan, in the course of the capsular organization, favours and potentiates the correct proliferation and organization of the tissue, rather than sustaining reactive processes leading to scar formation. N-carboxybutyl chitosan stimulates physiologically the tissue repair process and favours angiogenesis, whilst depressing fibrogenesis to a certain extent. Applications are envisaged in the treatment of wounds and in plastic surgery.
KW - angiogenesis
KW - Chitosan
KW - tissue regeneration
UR - http://www.scopus.com/inward/record.url?scp=0025995876&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025995876&partnerID=8YFLogxK
U2 - 10.1016/0142-9612(91)90036-A
DO - 10.1016/0142-9612(91)90036-A
M3 - Article
C2 - 1713079
AN - SCOPUS:0025995876
VL - 12
SP - 287
EP - 291
JO - Biomaterials
JF - Biomaterials
SN - 0142-9612
IS - 3
ER -