Morphological study of the capsular organization around tissue expanders coated with N-carboxybutyl chitosan

G. Biagini, A. Pugnaloni, A. Damadei, A. Bertani, A. Belligolli, V. Bicchiega, R. Muzzarelli

Research output: Contribution to journalArticle

Abstract

Expanders coated with N-carboxybutyl chitosan were inserted into surgical wounds in the dorsal skin of rabbits and the formation of capsular tissue was studied by scanning electron microscopy and transmission electron microscopy. N-carboxybutyl chitosan, in the course of the capsular organization, favours and potentiates the correct proliferation and organization of the tissue, rather than sustaining reactive processes leading to scar formation. N-carboxybutyl chitosan stimulates physiologically the tissue repair process and favours angiogenesis, whilst depressing fibrogenesis to a certain extent. Applications are envisaged in the treatment of wounds and in plastic surgery.

Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalBiomaterials
Volume12
Issue number3
DOIs
Publication statusPublished - 1991

Keywords

  • angiogenesis
  • Chitosan
  • tissue regeneration

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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