Abstract
Expanders coated with N-carboxybutyl chitosan were inserted into surgical wounds in the dorsal skin of rabbits and the formation of capsular tissue was studied by scanning electron microscopy and transmission electron microscopy. N-carboxybutyl chitosan, in the course of the capsular organization, favours and potentiates the correct proliferation and organization of the tissue, rather than sustaining reactive processes leading to scar formation. N-carboxybutyl chitosan stimulates physiologically the tissue repair process and favours angiogenesis, whilst depressing fibrogenesis to a certain extent. Applications are envisaged in the treatment of wounds and in plastic surgery.
| Original language | English |
|---|---|
| Pages (from-to) | 287-291 |
| Number of pages | 5 |
| Journal | Biomaterials |
| Volume | 12 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1991 |
Keywords
- angiogenesis
- Chitosan
- tissue regeneration
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomedical Engineering
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Biagini, G., Pugnaloni, A., Damadei, A., Bertani, A., Belligolli, A., Bicchiega, V., & Muzzarelli, R. (1991). Morphological study of the capsular organization around tissue expanders coated with N-carboxybutyl chitosan. Biomaterials, 12(3), 287-291. https://doi.org/10.1016/0142-9612(91)90036-A