Morphological study of the capsular organization around tissue expanders coated with N-carboxybutyl chitosan

G. Biagini, A. Pugnaloni, A. Damadei, A. Bertani, A. Belligolli, V. Bicchiega, R. Muzzarelli

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Expanders coated with N-carboxybutyl chitosan were inserted into surgical wounds in the dorsal skin of rabbits and the formation of capsular tissue was studied by scanning electron microscopy and transmission electron microscopy. N-carboxybutyl chitosan, in the course of the capsular organization, favours and potentiates the correct proliferation and organization of the tissue, rather than sustaining reactive processes leading to scar formation. N-carboxybutyl chitosan stimulates physiologically the tissue repair process and favours angiogenesis, whilst depressing fibrogenesis to a certain extent. Applications are envisaged in the treatment of wounds and in plastic surgery.

Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalBiomaterials
Volume12
Issue number3
DOIs
Publication statusPublished - 1991

Fingerprint

Tissue Expansion Devices
Chitosan
Tissue
Plastic Surgery
Transmission Electron Microscopy
Electron Scanning Microscopy
Surgery
Cicatrix
Skin
Repair
Rabbits
Transmission electron microscopy
Scanning electron microscopy
Wounds and Injuries
N-carboxybutyl chitosan

Keywords

  • angiogenesis
  • Chitosan
  • tissue regeneration

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

Morphological study of the capsular organization around tissue expanders coated with N-carboxybutyl chitosan. / Biagini, G.; Pugnaloni, A.; Damadei, A.; Bertani, A.; Belligolli, A.; Bicchiega, V.; Muzzarelli, R.

In: Biomaterials, Vol. 12, No. 3, 1991, p. 287-291.

Research output: Contribution to journalArticle

Biagini, G, Pugnaloni, A, Damadei, A, Bertani, A, Belligolli, A, Bicchiega, V & Muzzarelli, R 1991, 'Morphological study of the capsular organization around tissue expanders coated with N-carboxybutyl chitosan', Biomaterials, vol. 12, no. 3, pp. 287-291. https://doi.org/10.1016/0142-9612(91)90036-A
Biagini, G. ; Pugnaloni, A. ; Damadei, A. ; Bertani, A. ; Belligolli, A. ; Bicchiega, V. ; Muzzarelli, R. / Morphological study of the capsular organization around tissue expanders coated with N-carboxybutyl chitosan. In: Biomaterials. 1991 ; Vol. 12, No. 3. pp. 287-291.
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