Abstract
Expanders coated with N-carboxybutyl chitosan were inserted into surgical wounds in the dorsal skin of rabbits and the formation of capsular tissue was studied by scanning electron microscopy and transmission electron microscopy. N-carboxybutyl chitosan, in the course of the capsular organization, favours and potentiates the correct proliferation and organization of the tissue, rather than sustaining reactive processes leading to scar formation. N-carboxybutyl chitosan stimulates physiologically the tissue repair process and favours angiogenesis, whilst depressing fibrogenesis to a certain extent. Applications are envisaged in the treatment of wounds and in plastic surgery.
Original language | English |
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Pages (from-to) | 287-291 |
Number of pages | 5 |
Journal | Biomaterials |
Volume | 12 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1991 |
Keywords
- angiogenesis
- Chitosan
- tissue regeneration
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomedical Engineering