TY - JOUR
T1 - Morphology and Molecular Features of Rare Colorectal Carcinoma Histotypes
AU - Remo, Andrea
AU - Fassan, Matteo
AU - Vanoli, Alessandro
AU - Bonetti, Luca Reggiani
AU - Barresi, Valeria
AU - Tatangelo, Fabiana
AU - Gafà, Roberta
AU - Giordano, Guido
AU - Pancione, Massimo
AU - Grillo, Federica
AU - Mastracci, Luca
PY - 2019/7/23
Y1 - 2019/7/23
N2 - Several histopathological variants of colorectal carcinoma can be distinguished, some associated with specific molecular profiles. However, in routine practice, ninety/ninety-five percent of all large bowel tumors are diagnosed as conventional adenocarcinoma, even though they are a heterogeneous group including rare histotypes, which are often under-recognized. Indeed, colorectal cancer exhibits differences in incidence, location of tumor, pathogenesis, molecular pathways and outcome depending on histotype. The aim is therefore to review the morphological and molecular features of these rare variants of intestinal carcinomas which may hold the key to differences in prognosis and treatment.
AB - Several histopathological variants of colorectal carcinoma can be distinguished, some associated with specific molecular profiles. However, in routine practice, ninety/ninety-five percent of all large bowel tumors are diagnosed as conventional adenocarcinoma, even though they are a heterogeneous group including rare histotypes, which are often under-recognized. Indeed, colorectal cancer exhibits differences in incidence, location of tumor, pathogenesis, molecular pathways and outcome depending on histotype. The aim is therefore to review the morphological and molecular features of these rare variants of intestinal carcinomas which may hold the key to differences in prognosis and treatment.
U2 - 10.3390/cancers11071036
DO - 10.3390/cancers11071036
M3 - Article
VL - 11
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 7
ER -