Victor J. Ferrans, Eloisa Arbustini, Elling E. Eidbo, Michael Jones

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Calcific deposits are the most important complication that develops in cardiac valvular bioprostheses (BP) after implantation. Such deposits are found in the majority of BP implanted for greater than 3 years, and their importance relates to their becoming the cause of BP stenosis, because of the rigidity that they impart to the cusps, and BP regurgitation, because they often lead to cuspal perforation. The 2 most important types of calcific deposits in implanted BP involve cuspal collagen (intrinsic calcification) and surface thrombi (extrinsic calcification). A number of host-related factors and implant-related factors are thought to be important in the calcification of BP. Host-related factors include young age of the patient, chronic renal disease and hyperparathyroidism. Among implant-related factors are: the type of tissue in the BP (porcine aortic valve, bovine or porcine parietal pericardium, human dura mater), the nature of the preimplantation chemical processing (glutaraldehyde, formaldehyde, glycerol), and the penetration, into the implanted BP, of proteins containing high levels of gamma -carboxglutamic acid, a calcium-binding amino acid.

Original languageEnglish
Title of host publicationUnknown Host Publication Title
PublisherAssoc for the Advancement of Medical Instrumentation
Number of pages1
ISBN (Print)0910275343
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Engineering(all)


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