Morphology of experimentally induced complexes of mitochondria and club like protrusions in rat hepatocytes

W. Djaczenko, E. Garaci

Research output: Contribution to journalArticlepeer-review


The authors describe previously unreported, morphological modifications of club like protrusions observed during experiments on the effects of Vitamin E and essential fatty acid depletion on rat hepatocytes. The most frequent modification was the increase in the number and size of club like protrusions. The mean number of experimental club like protrusions per one side of hepatocytes was 3.93 and the mean volume was 1.052 μm3 (the corresponding control values were 1.88 and 0.608 μm3). Other structural modifications consisted in the association of club like protrusions with mitochondria never observed in the control material. Several mitochondria could surround one club like protrusion or one greatly enlarged mitochondrion enveloped several club like protrusions. The association of mitochondria and experimental club like protrusions was always intimate and constitutes a new morphological entity. This entity resembles similar morphological entities described in the literature, and referred to as 'mitochondrial pumps'. The functional significance of the association between club like protrusions and mitochondria is discussed.

Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalJournal of Microscopy
Issue number2
Publication statusPublished - 1974

ASJC Scopus subject areas

  • Instrumentation


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