Morphometric analysis of liver and kidney peroxisomes in lactating rats and their pups after treatment with the peroxisomal proliferator di-(2-ethylexyl)phthalate

Stefania Stefanini, Barbara Serafini, Roberta Nardacci, Stefano Farioli Vecchioli, Sandra Moreno, Claudia Sartori

Research output: Contribution to journalArticlepeer-review

Abstract

Di-(2-ethylexyl)phthalate (DEHP) administered to adult lactating rats from delivery to weaning induces age- and organ-specific modifications of the peroxisomal morphometric parameters (VV, NA and D) in the liver and kidney of both rats and their pups. In both tissues, peroxisomal relative volume and catalase biochemical activity show a similar pattern during the development, as well as under DEHP treatment. Morphometric results suggest that two modalities of peroxisomal proliferation exist, involving: a) increases in both number and mean diameter of the organelles; b) a purely numerical increase of the organelles, accompanied by a remarkable decrement in their mean diameter. A peroxisomal population proliferated through the latter model appears unable to return to normal conditions, following treatment withdrawal. These two proliferation systems, the first implying a swelling and the latter a fragmentation of pre-existing peroxisomal profiles, are supposed to be tissue-specific in the adult animal. In particular, in the liver the 'swelling' model appears more suitable to explain peroxisome proliferation, while in the kidney this process would follow the 'fragmentation' model. Immature animals might instead show in both organs intermediate features of peroxisomal proliferation modalities.

Original languageEnglish
Pages (from-to)167-176
Number of pages10
JournalBiology of the cell / under the auspices of the European Cell Biology Organization
Volume85
Issue number2-3
DOIs
Publication statusPublished - 1995

Keywords

  • catalase cytochemistry
  • electron microscopy
  • morphometry
  • neonatal rat
  • plasticizer

ASJC Scopus subject areas

  • Cell Biology

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