Morphometric vertebral fractures in breast cancer patients treated with adjuvant aromatase inhibitor therapy: A cross-sectional study

Rebecca Pedersini, S Monteverdi, G Mazziotti, Vito Amoroso, E Roca, F Maffezzoni, Lucia Vassalli, F Rodella, AM Formenti, S Frara, R Maroldi, A Berruti, Edda Lucia Simoncini, A Giustina

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Abstract

Background The impact of long-term adjuvant therapy with aromatase inhibitors (AIs) on vertebral fracture (VF) risk is still unclear. Objective In this cross-sectional study, we explored the prevalence and determinants of VFs in breast cancer (BC) patients before and during AI therapy. Each woman underwent a dual-energy X-ray absorptiometry (DXA) to evaluate bone mineral density (BMD) and identify VFs by a quantitative morphometric approach. Blood samples were collected to measure serum hormone and calcium levels. Results We consecutively included 263 postmenopausal women with hormone receptor-positive early BC. One-hundred-sixty-nine women were AI-naïve, and 94 were AI-treated. AI-treated patients had lower BMD at total hip (p = 0.01) and lumbar spine (p = 0.03), higher serum vitamin D (p 
Original languageEnglish
Pages (from-to)147-152
Number of pages6
JournalBone
Volume97
Issue number16
DOIs
Publication statusPublished - 2017

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Aromatase Inhibitors
Cross-Sectional Studies
Breast Neoplasms
Bone Density
Hormones
Therapeutics
Photon Absorptiometry
Serum
Vitamin D
Hip
Spine
Calcium

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Morphometric vertebral fractures in breast cancer patients treated with adjuvant aromatase inhibitor therapy: A cross-sectional study. / Pedersini, Rebecca; Monteverdi, S; Mazziotti, G; Amoroso, Vito; Roca, E; Maffezzoni, F; Vassalli, Lucia; Rodella, F; Formenti, AM; Frara, S; Maroldi, R; Berruti, A; Simoncini, Edda Lucia; Giustina, A.

In: Bone, Vol. 97, No. 16, 2017, p. 147-152.

Research output: Contribution to journalArticle

Pedersini, R, Monteverdi, S, Mazziotti, G, Amoroso, V, Roca, E, Maffezzoni, F, Vassalli, L, Rodella, F, Formenti, AM, Frara, S, Maroldi, R, Berruti, A, Simoncini, EL & Giustina, A 2017, 'Morphometric vertebral fractures in breast cancer patients treated with adjuvant aromatase inhibitor therapy: A cross-sectional study', Bone, vol. 97, no. 16, pp. 147-152. https://doi.org/10.1016/j.bone.2017.01.013
Pedersini, Rebecca ; Monteverdi, S ; Mazziotti, G ; Amoroso, Vito ; Roca, E ; Maffezzoni, F ; Vassalli, Lucia ; Rodella, F ; Formenti, AM ; Frara, S ; Maroldi, R ; Berruti, A ; Simoncini, Edda Lucia ; Giustina, A. / Morphometric vertebral fractures in breast cancer patients treated with adjuvant aromatase inhibitor therapy: A cross-sectional study. In: Bone. 2017 ; Vol. 97, No. 16. pp. 147-152.
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abstract = "Background The impact of long-term adjuvant therapy with aromatase inhibitors (AIs) on vertebral fracture (VF) risk is still unclear. Objective In this cross-sectional study, we explored the prevalence and determinants of VFs in breast cancer (BC) patients before and during AI therapy. Each woman underwent a dual-energy X-ray absorptiometry (DXA) to evaluate bone mineral density (BMD) and identify VFs by a quantitative morphometric approach. Blood samples were collected to measure serum hormone and calcium levels. Results We consecutively included 263 postmenopausal women with hormone receptor-positive early BC. One-hundred-sixty-nine women were AI-na{\"i}ve, and 94 were AI-treated. AI-treated patients had lower BMD at total hip (p = 0.01) and lumbar spine (p = 0.03), higher serum vitamin D (p ",
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AU - Pedersini, Rebecca

AU - Monteverdi, S

AU - Mazziotti, G

AU - Amoroso, Vito

AU - Roca, E

AU - Maffezzoni, F

AU - Vassalli, Lucia

AU - Rodella, F

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AU - Frara, S

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AB - Background The impact of long-term adjuvant therapy with aromatase inhibitors (AIs) on vertebral fracture (VF) risk is still unclear. Objective In this cross-sectional study, we explored the prevalence and determinants of VFs in breast cancer (BC) patients before and during AI therapy. Each woman underwent a dual-energy X-ray absorptiometry (DXA) to evaluate bone mineral density (BMD) and identify VFs by a quantitative morphometric approach. Blood samples were collected to measure serum hormone and calcium levels. Results We consecutively included 263 postmenopausal women with hormone receptor-positive early BC. One-hundred-sixty-nine women were AI-naïve, and 94 were AI-treated. AI-treated patients had lower BMD at total hip (p = 0.01) and lumbar spine (p = 0.03), higher serum vitamin D (p 

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