Morphophenotypic changes in human multistep hepatocarcinogenesis with translational implications

A. Sciarra, L. Di Tommaso, M. Nakano, A. Destro, G. Torzilli, M. Donadon, M. Maggioni, S. Bosari, Gaetano Bulfamante, Mitsuhiro Matsuda, Hideki Fujii, Tomoaki Ichikawa, Hiroyuki Morisaka, Koichi Sano, Shoji Ichikawa, M. Roncalli

Research output: Contribution to journalArticle


Background & Aims Human hepatocarcinogenesis in cirrhosis is thought to be multistep and characterized by a spectrum of nodular lesions, ranging from low to high grade dysplastic nodules (LGDN and HGDN) to early and progressed hepatocellular carcinoma (eHCC and pHCC). The aim of this study was to investigate the morphophenotypical changes of this sequence and their potential translational significance. Methods We scored the vascular profile, ductular reaction/stromal invasion and overexpression of five biomarkers (GPC3, HSP70, GS, CHC, and EZH2), in a series of 100 resected nodules (13 LGDN, 16 HGDN, 42 eHCC and 29 small pHCC). Results The score separated the four groups of nodules as individual entities (p
Original languageEnglish
Pages (from-to)87-93
Number of pages7
JournalJournal of Hepatology
Issue number1
Publication statusPublished - 2016

Cite this