Mortality after the treatment of hyperthyroidism with radioactive iodine

J. A. Franklyn, P. Maisonneuve, M. C. Sheppard, J. Betteridge, P. Boyle

Research output: Contribution to journalArticlepeer-review


Background: Hyperthyroidism affects many organ systems, but the effects are usually considered reversible. The long-term effects of hyperthyroidism on mortality are not known. Methods: We conducted a population-based study of mortality in a cohort of 7209 subjects with hyperthyroidism who were treated with radioactive iodine in Birmingham, United Kingdom, between 1950 and 1989. The vital status of the subjects was determined on March 1, 1996, and causes of death were ascertained for those who had died. The data on the causes of death were compared with data on age-specific mortality in England and Wales. The standardized mortality ratio was used as a measure of relative risk, and the effect of covariates on mortality was assessed by regression analysis. Results: During 105,028 person-years of follow-up, 3611 subjects died; the expected number of deaths was 3186 (standardized mortality ratio, 1.1; 95 percent confidence interval, 1.1 to 1.2; P

Original languageEnglish
Pages (from-to)712-718
Number of pages7
JournalNew England Journal of Medicine
Issue number11
Publication statusPublished - Mar 12 1998

ASJC Scopus subject areas

  • Medicine(all)


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