Mortality and transfusion requirements in COVID-19 hospitalized italian patients according to severity of the disease

Elvira Grandone, Raffaele Pesavento, Giovanni Tiscia, Antonio De Laurenzo, Davide Ceccato, Maria Teresa Sartori, Lucia Mirabella, Gilda Cinnella, Mario Mastroianno, Lidia Dalfino, Donatella Colaizzo, Roberto Vettor, Angelo Ostuni, Maurizio Margaglione

Research output: Contribution to journalArticlepeer-review


There is paucity of data on the transfusion need and its impact on the overall mortality in patients with COVID-19. We explored mortality in hospitalized patients with COVID-19 who required transfusions. Information on clinical variables and in-hospital mortality were obtained from medical records of 422 patients admitted to medical wards or the Intensive Care Unit (ICU). In-hospital mortality occurred in 147 (34.8%) patients, 94 (63.9%) of whom were admitted to the ICU. The median fatalities age was 77 years (IQR 14). Overall, 100 patients (60 males) received transfusion during hospitalization. The overall mortality was significantly and independently associated with age, ICU admission, Chronic Kidney Disease (CKD), and the number of transfused Red Blood Cell (RBC) units. Specifically, CKD was associated with mortality in patients admitted to medical wards, whereas the number of transfused RBC units predicted mortality in those admitted to the ICU. Transfusion strongly interacted with the admission to ICU (OR: 9.9; 95% CI: 2.5–40.0). In patients with COVID-19, age is one of the strongest risk factors in predicting mortality independently of the disease’s severity. CKD confers a higher risk of mortality in patients admitted to medical wards. In those admitted to the ICU, the more RBC units are transfused, the more mortality increases.

Original languageEnglish
Article number242
Pages (from-to)1-8
Number of pages8
JournalJournal of Clinical Medicine
Issue number2
Publication statusPublished - Jan 2 2021


  • COVID-19
  • ICU
  • Medical ward
  • Mortality
  • Transfusion

ASJC Scopus subject areas

  • Medicine(all)


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