Mortality at 120 days after prostatic biopsy: A population-based study of 22,175 men

Andrea Gallina, Nazareno Suardi, Francesco Montorsi, Umberto Capitanio, Claudio Jeldres, Fred Saad, Markus Graefen, Shahrokh F. Shariat, Hugues Widmer, Philippe Arjane, François Péloquin, Paul Perrotte, Pierre I. Karakiewicz

Research output: Contribution to journalArticle


Trans-rectal ultrasound guided biopsy of the prostate represents the diagnostic standard for prostate cancer, but its mortality rate has never been examined. We performed a population-based study of 120-day mortality after prostate biopsy in 22,175 patients, who underwent prostate biopsy between 1989 and 2000. The control group consisted of 1,778 men aged 65-85 years (median 69.5), who did not undergo a biopsy. Univariable and multivariable logistic regression analyses were performed in 11,087 of 22,175 (50%) men subjected to prostate biopsy, to identify predictors of 120-day mortality. Variables were age at biopsy, baseline Charlson comorbidity index and cumulative number of biopsy procedures. We externally validated the model's predictors in the remaining 50% of men. Overall 120-day mortality after biopsy was 1.3% versus 0.3% (p <0.001) in the control group. Of men aged ≤60 years, 0.2% died within 120 days versus 2.5% aged 76-80. Zero Charlson comorbidity score yielded 0.7% mortality versus 2.2%, if 3-4. First ever biopsy procedures carried a higher mortality risk than subsequent procedures (1.4 vs. 0.8 vs. 0.6%). In the multivariable model, first ever biopsy, increasing age and comorbidity predicted higher mortality. Overall, the model's variables were 79% accurate in predicting the probability of 120-day mortality after biopsy. In conclusion, our data suggest that prostate biopsy might predispose to higher mortality rate. The certainty of this association remains to be proven.

Original languageEnglish
Pages (from-to)647-652
Number of pages6
JournalInternational Journal of Cancer
Issue number3
Publication statusPublished - Aug 1 2008


  • Diagnosis
  • Mortality
  • Nomogram
  • Prostate biopsy
  • Prostate cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Gallina, A., Suardi, N., Montorsi, F., Capitanio, U., Jeldres, C., Saad, F., Graefen, M., Shariat, S. F., Widmer, H., Arjane, P., Péloquin, F., Perrotte, P., & Karakiewicz, P. I. (2008). Mortality at 120 days after prostatic biopsy: A population-based study of 22,175 men. International Journal of Cancer, 123(3), 647-652.