Mortality from second tumour among long-term survivors of retinoblastoma: A retrospective analysis of the Italian retinoblastoma registry

A. Acquaviva, L. Ciccolallo, R. Rondelli, A. Balistreri, R. Ancarola, R. Cozza, D. Hadjistilianou, S. De Francesco, P. Toti, G. Pastore, R. Haupt, M. Carli, N. Santoro, Andrea Di Cataldo, A. Fiorillo, P. Indolfi, P. Nucci, A. Sandri, F. Porta, A. B. PorcaroP. Tamaro, G. Morgese

Research output: Contribution to journalArticlepeer-review

Abstract

Survivors of retinoblastoma (Rb) are at high risk of dying from second malignant tumour. The occurrence of second malignant neoplasm (SMN) and related mortality in a cohort of 1111 cases from the Italian Retinoblastoma Registry was analysed, considering the possible role of both genetic and iatrogenic causes. Rb patients had a greater than 10-fold excess in overall mortality compared with the general population (standardized mortality ratio (SMR) 10.73, 95% CI 9.00-12.80). Their excess risk attributable to cancers other than Rb was 14.93 95% CI 10.38-21.49). Survivors of hereditary Rb had an SMR for all causes of 16.25 (95% CI 13.20-20.00), whereas their SMR for all cancers was 25.72 (95% CI 17.38-38.07). Survivors of unilateral sporadic Rb had an SMR of 4.12 from all cancers (95% CI 1.55-10.98) and a much higher excess for overall mortality (SMR 13.34, 95% CI 10.74-16.56). As expected, survivors of hereditary Rb had higher mortality from cancers of the bone (SMR 391.90, 95% CI 203.90-753.20) and soft tissue (SMR 453.00, 95% CI 203.50-1008.40), small intestine (SMR 1375.50, 95% CI 344.00-5499.70), nasal cavity (SMR 13.71, 95% CI 1.93-97.35) and cancers of the brain and central nervous system (SMR 41.14, 95% CI 13.2-127.55).

Original languageEnglish
Pages (from-to)5350-5357
Number of pages8
JournalOncogene
Volume25
Issue number38
DOIs
Publication statusPublished - Aug 28 2006

Keywords

  • Chemotherapy
  • Mortality
  • Radiotherapy
  • Retinoblastoma
  • Second primary neoplasm

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

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