TY - JOUR
T1 - Mortality in an Italian nursing home during COVID-19 pandemic
T2 - correlation with gender, age, ADL, vitamin D supplementation, and limitations of the diagnostic tests
AU - Cangiano, Biagio
AU - Fatti, Letizia Maria
AU - Danesi, Leila
AU - Gazzano, Giacomo
AU - Croci, Marina
AU - Vitale, Giovanni
AU - Gilardini, Luisa
AU - Bonadonna, Stefania
AU - Chiodini, Iacopo
AU - Caparello, Chiara Francesca
AU - Conti, Antonio
AU - Persani, Luca
AU - Stramba-Badiale, Marco
AU - Bonomi, Marco
N1 - Funding Information:
We thank Dr. Lydia Grixti for language editing.
Publisher Copyright:
© 2020, AGING. All rights reserved
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/12/31
Y1 - 2020/12/31
N2 - Introduction: The COVID-19 pandemic caused an increased mortality in nursing homes due to its quick spread and the age-related high lethality. Results: We observed a two-month mortality of 40%, compared to 6.4% in the previous year. This increase was seen in both COVID-19 positive (43%) and negative (24%) residents, but 8 patients among those testing negative on the swab, tested positive on serological tests. Increased mortality was associated with male gender, older age, no previous vitamin D supplementation and worse “activities of daily living (ADL)” scores, such as Barthel index, Tinetti scale and S.OS.I.A. classification. Conclusion: Our data confirms a higher geriatric mortality due to COVID-19. Negative residents also had higher mortality, which we suspect is secondary to preanalytical error and a low sensitivity of the swab test in poorly compliant subjects. Male gender, older age and low scores on ADL scales (probably due to immobility) are risk factors for COVID-19 related mortality. Finally, mortality was inversely associated with vitamin D supplementation. Design: In this observational study, we described the two-month mortality among the 157 residents (age 60-100) of a nursing home after Sars-CoV-2 spreading, reporting the factors associated with the outcome. We also compared the diagnostic tests for Sars-CoV-2.
AB - Introduction: The COVID-19 pandemic caused an increased mortality in nursing homes due to its quick spread and the age-related high lethality. Results: We observed a two-month mortality of 40%, compared to 6.4% in the previous year. This increase was seen in both COVID-19 positive (43%) and negative (24%) residents, but 8 patients among those testing negative on the swab, tested positive on serological tests. Increased mortality was associated with male gender, older age, no previous vitamin D supplementation and worse “activities of daily living (ADL)” scores, such as Barthel index, Tinetti scale and S.OS.I.A. classification. Conclusion: Our data confirms a higher geriatric mortality due to COVID-19. Negative residents also had higher mortality, which we suspect is secondary to preanalytical error and a low sensitivity of the swab test in poorly compliant subjects. Male gender, older age and low scores on ADL scales (probably due to immobility) are risk factors for COVID-19 related mortality. Finally, mortality was inversely associated with vitamin D supplementation. Design: In this observational study, we described the two-month mortality among the 157 residents (age 60-100) of a nursing home after Sars-CoV-2 spreading, reporting the factors associated with the outcome. We also compared the diagnostic tests for Sars-CoV-2.
KW - activities of daily living
KW - COVID-19
KW - hydroxychloroquine
KW - nasopharyngeal swab
KW - sensitivity and specificity
KW - serology
UR - http://www.scopus.com/inward/record.url?scp=85098869094&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85098869094&partnerID=8YFLogxK
U2 - 10.18632/aging.202307
DO - 10.18632/aging.202307
M3 - Article
C2 - 33353888
AN - SCOPUS:85098869094
VL - 12
SP - 24522
EP - 24534
JO - Aging
JF - Aging
SN - 1945-4589
IS - 24
ER -