TY - JOUR
T1 - Mortality in Patients after a Recent Myocardial Infarction
T2 - A Randomized, Placebo-Controlled Trial of Azimilide Using Heart Rate Variability for Risk Stratification
AU - Camm, A. John
AU - Pratt, Craig M.
AU - Schwartz, Peter J.
AU - Al-Khalidi, Hussein R.
AU - Spyt, Maria J.
AU - Holroyde, Michael J.
AU - Karam, Roger
AU - Sonnenblick, Edmund H.
AU - Brum, Jose M G
PY - 2004/3/2
Y1 - 2004/3/2
N2 - Background - Depressed left ventricular function (LVF) and low heart rate variability (HRV) identify patients at risk of increased mortality after myocardial infarction (MI). Azimilide, a novel class III antiarrhythmic drug, was investigated for its effects on mortality in patients with depressed LVF after recent MI and in a subpopulation of patients with low HRV. Methods and Results - A total of 3717 post-MI patients with depressed LVF were enrolled in this randomized, placebo-controlled, double-blind study of azimilide 100 mg on all-cause mortality. Placebo patients with low HRV had a significantly higher 1-year mortality than those with high HRV (>20 U; 15% versus 9.5%, P
AB - Background - Depressed left ventricular function (LVF) and low heart rate variability (HRV) identify patients at risk of increased mortality after myocardial infarction (MI). Azimilide, a novel class III antiarrhythmic drug, was investigated for its effects on mortality in patients with depressed LVF after recent MI and in a subpopulation of patients with low HRV. Methods and Results - A total of 3717 post-MI patients with depressed LVF were enrolled in this randomized, placebo-controlled, double-blind study of azimilide 100 mg on all-cause mortality. Placebo patients with low HRV had a significantly higher 1-year mortality than those with high HRV (>20 U; 15% versus 9.5%, P
KW - Antiarrhythmia agents
KW - Azimilide
KW - Heart rate
KW - Trials
UR - http://www.scopus.com/inward/record.url?scp=1442335812&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1442335812&partnerID=8YFLogxK
U2 - 10.1161/01.CIR.0000117090.01718.2A
DO - 10.1161/01.CIR.0000117090.01718.2A
M3 - Article
C2 - 14967728
AN - SCOPUS:1442335812
VL - 109
SP - 990
EP - 996
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 8
ER -