TY - JOUR
T1 - Mortality in patients with cancer and coronavirus disease 2019: A systematic review and pooled analysis of 52 studies
AU - Saini, Kamal S.
AU - Tagliamento, Marco
AU - Lambertini, Matteo
AU - McNally, Richard
AU - Romano, Marco
AU - Leone, Manuela
AU - Curigliano, Giuseppe
AU - de Azambuja, Evandro
PY - 2020/11
Y1 - 2020/11
N2 - Background: Patients with coronavirus disease 2019 (COVID-19) who have underlying malignancy have a higher mortality rate compared with those without cancer, although the magnitude of such excess risk is not clearly defined. We performed a systematic review and pooled analysis to provide precise estimates of the mortality rate among patients with both cancer and COVID-19. Methods: A systematic literature search involving peer-reviewed publications, preprints and conference proceedings up to July 16, 2020, was performed. The primary end-point was the case fatality rate (CFR), defined as the rate of death among patients with cancer and COVID-19. The CFR was assessed with a random effects model, which was used to derive a pooled CFR and its 95% confidence interval (CI). Results: Fifty-two studies, involving a total of 18,650 patients with both COVID-19 and cancer, were selected for the pooled analysis. A total of 4243 deaths were recorded in this population. The probability of death was 25.6% (95% CI: 22.0%–29.5%; I2 = 48.9%) in this patient population. Conclusions: Patients with cancer who develop COVID-19 have high probability of mortality. Appropriate and aggressive preventive measures must be taken to reduce the risk of COVID-19 in patients with cancer and to optimally manage those who do contract the infection.
AB - Background: Patients with coronavirus disease 2019 (COVID-19) who have underlying malignancy have a higher mortality rate compared with those without cancer, although the magnitude of such excess risk is not clearly defined. We performed a systematic review and pooled analysis to provide precise estimates of the mortality rate among patients with both cancer and COVID-19. Methods: A systematic literature search involving peer-reviewed publications, preprints and conference proceedings up to July 16, 2020, was performed. The primary end-point was the case fatality rate (CFR), defined as the rate of death among patients with cancer and COVID-19. The CFR was assessed with a random effects model, which was used to derive a pooled CFR and its 95% confidence interval (CI). Results: Fifty-two studies, involving a total of 18,650 patients with both COVID-19 and cancer, were selected for the pooled analysis. A total of 4243 deaths were recorded in this population. The probability of death was 25.6% (95% CI: 22.0%–29.5%; I2 = 48.9%) in this patient population. Conclusions: Patients with cancer who develop COVID-19 have high probability of mortality. Appropriate and aggressive preventive measures must be taken to reduce the risk of COVID-19 in patients with cancer and to optimally manage those who do contract the infection.
KW - Cancer
KW - CFR
KW - COVID-19
KW - Death rate
KW - Malignancy
KW - Mortality
KW - Pandemic
KW - SARS-CoV-2
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U2 - 10.1016/j.ejca.2020.08.011
DO - 10.1016/j.ejca.2020.08.011
M3 - Article
AN - SCOPUS:85091244339
VL - 139
SP - 43
EP - 50
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0959-8049
ER -