Mosaicplasty versus matrix-assisted autologous chondrocyte transplantation for knee cartilage defects: A long-term clinical and imaging evaluation

Stefano Zaffagnini, Angelo Boffa, Luca Andriolo, Davide Reale, Maurizio Busacca, Alessandro Di Martino, Giuseppe Filardo

Research output: Contribution to journalArticlepeer-review

Abstract

Different surgical procedures have been proposed over the past few years to treat cartilage lesions. The aim of this study was to compare mosaicplasty and matrix-assisted autologous chondrocyte transplantation (MACT) at long-term follow-up. Forty-three patients were included: 20 mosaicplasty and 23 MACT. Patients were evaluated before and 12 years after surgery with the International Knee Documentation Committee (IKDC) subjective and objective scores for symptoms and function, and with the Tegner score for activity level. Magnetic Resonance Imaging (MRI) was used to evaluate repair tissue with the MOCART 2.0 score. Mosaicplasty and MACT showed good clinical and MRI results (IKDC subjective score 75.3 ± 21.8 and 81.8 ± 13.0, both p < 0.0005). Mosaicplasty presented a 10% reoperation rate and a 25% overall failure rate, while no failures were documented in MACT (p = 0.016). While size did not influence the results in the MACT group, mosaicplasty presented lower IKDC objective and Tegner scores in lesions bigger than 2 cm2 (p = 0.031 and p = 0.014, respectively). Mosaicplasty and MACT presented both satisfactory clinical and MRI results at long-term follow-up. However, for larger lesions, MACT presented better subjective and objective outcomes, as well as less failures, which should be considered when choosing the most suitable treatment for patients affected by knee cartilage lesions.

Original languageEnglish
Article number4615
Pages (from-to)1-13
Number of pages13
JournalApplied Sciences (Switzerland)
Volume10
Issue number13
DOIs
Publication statusPublished - Jul 1 2020

Keywords

  • ACI
  • Cartilage
  • Knee
  • MACT
  • Mosaicplasty
  • OAT
  • Osteochondral autologous transplantation
  • Scaffold

ASJC Scopus subject areas

  • Materials Science(all)
  • Instrumentation
  • Engineering(all)
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes

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