Abstract
More than 90% of HIV-1 infection in children is acquired by mother-to-child transmission. A recent evaluation in Europe estimated that one out of seven children born to HIV-1-infected women was infected, but transmission in Africa seems to be considerably higher. Factors influencing the risk of transmission include load and replicative properties of the virus as well as the neutralizing antibody response of the mother. A recently concluded trial with zidovudine administered to pregnant women and their newborn infants achieved a two-third reduction in the transmission rate. This knowledge together with a better understanding of timing of transmission is of extreme importance for further planning of focused interventional approaches to reduce transmission.
| Original language | English |
|---|---|
| Pages (from-to) | 59-65 |
| Number of pages | 7 |
| Journal | Current Opinion in Infectious Diseases |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1995 |
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ASJC Scopus subject areas
- Immunology
- Microbiology (medical)
Cite this
Mother-to-child transmission of HIV-1. / Scarlatti, G.; Jansson, M.
In: Current Opinion in Infectious Diseases, Vol. 8, No. 1, 1995, p. 59-65.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mother-to-child transmission of HIV-1
AU - Scarlatti, G.
AU - Jansson, M.
PY - 1995
Y1 - 1995
N2 - More than 90% of HIV-1 infection in children is acquired by mother-to-child transmission. A recent evaluation in Europe estimated that one out of seven children born to HIV-1-infected women was infected, but transmission in Africa seems to be considerably higher. Factors influencing the risk of transmission include load and replicative properties of the virus as well as the neutralizing antibody response of the mother. A recently concluded trial with zidovudine administered to pregnant women and their newborn infants achieved a two-third reduction in the transmission rate. This knowledge together with a better understanding of timing of transmission is of extreme importance for further planning of focused interventional approaches to reduce transmission.
AB - More than 90% of HIV-1 infection in children is acquired by mother-to-child transmission. A recent evaluation in Europe estimated that one out of seven children born to HIV-1-infected women was infected, but transmission in Africa seems to be considerably higher. Factors influencing the risk of transmission include load and replicative properties of the virus as well as the neutralizing antibody response of the mother. A recently concluded trial with zidovudine administered to pregnant women and their newborn infants achieved a two-third reduction in the transmission rate. This knowledge together with a better understanding of timing of transmission is of extreme importance for further planning of focused interventional approaches to reduce transmission.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028839059&partnerID=8YFLogxK
U2 - 10.1097/00001432-199502000-00013
DO - 10.1097/00001432-199502000-00013
M3 - Article
AN - SCOPUS:0028839059
VL - 8
SP - 59
EP - 65
JO - Current Opinion in Infectious Diseases
JF - Current Opinion in Infectious Diseases
SN - 0951-7375
IS - 1
ER -