Mother-to-child transmission of human immunodeficiency virus

P. Rossi, V. Moschese

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Transmission of HIV virus from an infected mother to her offspring is becoming the leading cause of spreading in the pediatric population. This is particularly burdensome in the pattern II countries where HIV infection has reached epidemic proportions and infection rates affect more women of childbearing age than men. During the last few years considerable effort has been directed at defining the optimal methods for identifying infants of HIV-infected mothers who will themselves prove to be infected because conventional serological assessment is impaired due to placental transfer of maternal IgG. At present, detection of specific IgA to HIV proteins, evaluation of autochthonous antibody production in vitro from infants' lymphocytes, and gene amplification of HIV DNA/RNA by polymerase chain reaction are the most promising procedures for early diagnosis within the first 6 months of life. Nevertheless all these techniques are cumbersome when evaluating specimens from the newborn child. Many studies have been performed to identify those maternal factors affecting the risk of vertical transmission. So far, none of them has shown real prognostic value. However, evaluation of maternal antibody response to functional epitopes of HIV envelope proteins such as the principal neutralizing domain, in some epidemiological settings, seems to correlate to a reduced rate of mother-to-child transmission.

Original languageEnglish
Pages (from-to)2419-2426
Number of pages8
JournalFASEB Journal
Volume5
Issue number10
Publication statusPublished - 1991

Fingerprint

Human immunodeficiency virus
Viruses
polymerase chain reaction
Mothers
HIV
maternal immunity
early diagnosis
HIV infections
antibody formation
neutralization
epitopes
Human Immunodeficiency Virus Proteins
neonates
Pediatrics
risk factors
lymphocytes
Lymphocytes
proteins
Antibodies
Polymerase chain reaction

Keywords

  • HIV detection
  • HIV-infected infants
  • HIV-infected mothers

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Mother-to-child transmission of human immunodeficiency virus. / Rossi, P.; Moschese, V.

In: FASEB Journal, Vol. 5, No. 10, 1991, p. 2419-2426.

Research output: Contribution to journalArticle

Rossi, P & Moschese, V 1991, 'Mother-to-child transmission of human immunodeficiency virus', FASEB Journal, vol. 5, no. 10, pp. 2419-2426.
Rossi, P. ; Moschese, V. / Mother-to-child transmission of human immunodeficiency virus. In: FASEB Journal. 1991 ; Vol. 5, No. 10. pp. 2419-2426.
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