Mother-to-child transmission of human immunodeficiency virus type 1: Correlation with neutralizing antibodies against primary isolates

G. Scarlatti, J. Albert, P. Rossi, V. Hodara, P. Biraghi, L. Muggiasca, E. M. Fenyo

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Abstract

The aim of this study was to investigate the influence of neutralizing antibodies in mother's serum on the risk of mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1). Sera from 20 HIV-1 infected mothers were analyzed for their ability to neutralize their own virus (autologous neutralization) and virus obtained from other mothers (heterologous neutralization). A statistically significant correlation was found between the capacity to neutralize 1 selected primary isolate and protection of the child from infection. Also, neutralizing antibodies against autologous virus were more frequently present in nontransmitting mothers than in transmitting mothers (5 and 2, respectively, of 10 mothers). The mothers with autologous neutralizing antibodies also neutralized at least 2 heterologous primary isolates. Thus, mothers with neutralizing antibodies to primary HIV-1 isolates have a reduced risk of infecting their children.

Original languageEnglish
Pages (from-to)207-210
Number of pages4
JournalJournal of Infectious Diseases
Volume168
Issue number1
Publication statusPublished - 1993

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ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

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