Mother to infant transmission of coinfection by human immunodeficiency virus and hepatitis C virus: Prevalence and clinical manifestations

G. Nigro, F. D'Orio, S. Catania, M. C. Badolato, S. Livadiotti, S. Bernardi, P. D'Argenio

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Abstract

The prevalence and the clinical course of hepatitis C virus (HCV) infections were studied in 23 HIV-1-infected children, who were born to 22 mothers with HIV-1/HCV coinfection. During the follow-up only two children (8.7%) showed persistent anti-HCV antibodies and circulating HCV RNA. Both children, who were aged 10 and 10.6 years respectively at the end of follow-up, had chronically-evolving liver disease and autoimmune thrombocytopenia but no signs of progressive HIV disease. Based on our experience, vertically-acquired HIV-1/HCV coinfection is less frequent than is generally reported and may be associated with the development of chronic thrombocytopenia in addition to liver disease. Moreover, perinatal HIV-1/HCV coinfection appears to be associated with a slow progression of HIV disease.

Original languageEnglish
Pages (from-to)453-457
Number of pages5
JournalArchives of Virology
Volume142
Issue number3
DOIs
Publication statusPublished - 1997

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ASJC Scopus subject areas

  • Genetics
  • Applied Microbiology and Biotechnology

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