Motor and cognitive performances of Parkinsonian patients in the on and off phases of the disease

Floriano Girotti; Francesco Carella; Maria Pia Grassi; Paola Soliveri; Riccardo Marano; Tommaso Caraceni

doi:10.1136/jnnp.49.6.657

Motor and cognitive performances of Parkinsonian patients in the on and off phases of the disease

Floriano Girotti, Francesco Carella, Maria Pia Grassi, Paola Soliveri, Riccardo Marano, Tommaso Caraceni

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

Twenty-one Parkinsonian patients were tested in on and off phases during chronic levodopa therapy for cognitive function, affective status, and evaluation of motor performance with reaction and movement times. A worsening ofmood was observed from the on to the off phase. No variation in cognitive performance was observed from the on to the off phase in spite of evident motor changes. Mood changes during on-off variations may reflect involvement of mesocortical and mesolimbic dopaminergic systems.

Original language	English
Pages (from-to)	657-660
Number of pages	4
Journal	Journal of Neurology, Neurosurgery and Psychiatry
Volume	49
Issue number	6
DOIs	https://doi.org/10.1136/jnnp.49.6.657
Publication status	Published - 1986

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Neuropsychology and Physiological Psychology
Neuroscience(all)
Psychiatry and Mental health

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AU - Marano, Riccardo

AU - Caraceni, Tommaso

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Motor and cognitive performances of Parkinsonian patients in the on and off phases of the disease

Abstract

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