Motor and cognitive performances of Parkinsonian patients in the on and off phases of the disease

Floriano Girotti, Francesco Carella, Maria Pia Grassi, Paola Soliveri, Riccardo Marano, Tommaso Caraceni

Research output: Contribution to journalArticle

Abstract

Twenty-one Parkinsonian patients were tested in on and off phases during chronic levodopa therapy for cognitive function, affective status, and evaluation of motor performance with reaction and movement times. A worsening ofmood was observed from the on to the off phase. No variation in cognitive performance was observed from the on to the off phase in spite of evident motor changes. Mood changes during on-off variations may reflect involvement of mesocortical and mesolimbic dopaminergic systems.

Original languageEnglish
Pages (from-to)657-660
Number of pages4
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume49
Issue number6
DOIs
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

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