TY - JOUR
T1 - Motor and Sensory Features of Cervical Dystonia Subtypes: Data From the Italian Dystonia Registry
AU - Di Biasio, Francesca
AU - Marchese, Roberta
AU - Abbruzzese, Giovanni
AU - Baldi, Ottavia
AU - Esposito, Marcello
AU - Silvestre, Francesco
AU - Tescione, Girolamo
AU - Berardelli, Alfredo
AU - Fabbrini, Giovanni
AU - Ferrazzano, Gina
AU - Pellicciari, Roberta
AU - Eleopra, Roberto
AU - Devigili, Grazia
AU - Bono, Francesco
AU - Santangelo, Domenico
AU - Bertolasi, Laura
AU - Altavista, Maria Concetta
AU - Moschella, Vincenzo
AU - Barone, Paolo
AU - Erro, Roberto
AU - Albanese, Alberto
AU - Scaglione, Cesa
AU - Liguori, Rocco
AU - Cotelli, Maria Sofia
AU - Cossu, Giovanni
AU - Ceravolo, Roberto
AU - Coletti Moja, Mario
AU - Zibetti, Maurizio
AU - Pisani, Antonio
AU - Petracca, Martina
AU - Tinazzi, Michele
AU - Maderna, Luca
AU - Girlanda, Paolo
AU - Magistrelli, Luca
AU - Misceo, Salvatore
AU - Romano, Marcello
AU - Minafra, Brigida
AU - Modugno, Nicola
AU - Aguggia, Marco
AU - Cassano, Daniela
AU - Defazio, Giovanni
AU - Avanzino, Laura
PY - 2020/8/26
Y1 - 2020/8/26
N2 - Introduction: Cervical dystonia (CD) is one of the most common forms of adult-onset isolated dystonia. Recently, CD has been classified according to the site of onset and spread, in different clinical subgroups, that may represent different clinical entities or pathophysiologic subtypes. In order to support this hypothesis, in this study we have evaluated whether different subgroups of CD, that clinically differ for site of onset and spread, also imply different sensorimotor features. Methods: Clinical and demographic data from 842 patients with CD from the Italian Dystonia Registry were examined. Motor features (head tremor and tremor elsewhere) and sensory features (sensory trick and neck pain) were investigated. We analyzed possible associations between motor and sensory features in CD subgroups [focal neck onset, no spread (FNO-NS); focal neck onset, segmental spread (FNO-SS); focal onset elsewhere with segmental spread to neck (FOE-SS); segmental neck involvement without spread (SNI)]. Results: In FNO-NS, FOE-SS, and SNI subgroups, head tremor was associated with the presence of tremor elsewhere. Sensory trick was associated with pain in patients with FNO-NS and with head tremor in patients with FNO-SS. Conclusion: The frequent association between head tremor and tremor elsewhere may suggest a common pathophysiological mechanism. Two mechanisms may be hypothesized for sensory trick: a gating mechanism attempting to reduce pain and a sensorimotor mechanism attempting to control tremor.
AB - Introduction: Cervical dystonia (CD) is one of the most common forms of adult-onset isolated dystonia. Recently, CD has been classified according to the site of onset and spread, in different clinical subgroups, that may represent different clinical entities or pathophysiologic subtypes. In order to support this hypothesis, in this study we have evaluated whether different subgroups of CD, that clinically differ for site of onset and spread, also imply different sensorimotor features. Methods: Clinical and demographic data from 842 patients with CD from the Italian Dystonia Registry were examined. Motor features (head tremor and tremor elsewhere) and sensory features (sensory trick and neck pain) were investigated. We analyzed possible associations between motor and sensory features in CD subgroups [focal neck onset, no spread (FNO-NS); focal neck onset, segmental spread (FNO-SS); focal onset elsewhere with segmental spread to neck (FOE-SS); segmental neck involvement without spread (SNI)]. Results: In FNO-NS, FOE-SS, and SNI subgroups, head tremor was associated with the presence of tremor elsewhere. Sensory trick was associated with pain in patients with FNO-NS and with head tremor in patients with FNO-SS. Conclusion: The frequent association between head tremor and tremor elsewhere may suggest a common pathophysiological mechanism. Two mechanisms may be hypothesized for sensory trick: a gating mechanism attempting to reduce pain and a sensorimotor mechanism attempting to control tremor.
KW - cervical dystonia
KW - pain
KW - sensory trick
KW - spread
KW - tremor
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U2 - 10.3389/fneur.2020.00906
DO - 10.3389/fneur.2020.00906
M3 - Article
AN - SCOPUS:85091048627
VL - 11
JO - Frontiers in Neurology
JF - Frontiers in Neurology
SN - 1664-2295
M1 - 906
ER -