Motor and somatosensory evoked potentials in hereditary spastic paraplegia

Luciana Pelosi, Bernado Lanzillo, Anna Perretti, Lucio Santoro, Lance Blumhardt, Giuseppe Caruso

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Motor evoked potentials (MEPs) from the arms and legs to transcranial stimulation of the motor cortex and somatosensory evoked potentials (SSEPs) from stimulation of the nerves of the arms and legs, were recorded in 11 patients with hereditary spastic paraplegia. Electrophysiological abnormalities were found to be distributed differently among the systems examined; the longer the pathway, the higher the incidence and severity of impairment. MEPs from the leg were either absent or clearly reduced or prolonged in all patients. Eight patients showed abnormal cortical SSEPs on stimulation of the leg (absent or reduced responses in four, slowed central conduction velocity in seven), but only two of these patients had abnormal MEPs from the arm (absent responses). Cortical SSEPs on stimulation of the median nerve were reduced in two patients. Mean values of amplitude and central conduction velocity for MEPs and SSEPs from thelegweresignificantlydifferentbetween patients and controls. Such differences were not found for either MEPs or SSEPs from the arm. This distribution ofabnormalities, which suggests a differential involvement of the spinal pathways, parallels the reported pathological pattern in which degeneration of axons is more common and severe in the motor and sensory fibres supplying the leg.

Original languageEnglish
Pages (from-to)1099-1102
Number of pages4
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume54
Issue number12
DOIs
Publication statusPublished - 1951

Fingerprint

Hereditary Spastic Paraplegia
Motor Evoked Potentials
Somatosensory Evoked Potentials
Leg
Arm
Median Nerve
Motor Cortex
Axons
Incidence

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Motor and somatosensory evoked potentials in hereditary spastic paraplegia. / Pelosi, Luciana; Lanzillo, Bernado; Perretti, Anna; Santoro, Lucio; Blumhardt, Lance; Caruso, Giuseppe.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 54, No. 12, 1951, p. 1099-1102.

Research output: Contribution to journalArticle

Pelosi, Luciana ; Lanzillo, Bernado ; Perretti, Anna ; Santoro, Lucio ; Blumhardt, Lance ; Caruso, Giuseppe. / Motor and somatosensory evoked potentials in hereditary spastic paraplegia. In: Journal of Neurology, Neurosurgery and Psychiatry. 1951 ; Vol. 54, No. 12. pp. 1099-1102.
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AU - Blumhardt, Lance

AU - Caruso, Giuseppe

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