Motor, cognitive and MRI aspects of corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP)

D. Monza, P. Souveri, V. Fetoni, D. Testa, S. Genitrini, M. Grisoli, M. Savoiardo, D. Radice, T. Caraceni, F. Girotti

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Abstract

CBD and PSP often show common clinical and pathological features and are therefore difficult to distinguish on clinical grounds alone. In an attempt to identify the most important features for clinical diagnosis of these diseases we compared motor, cognitive and NMR characteristics in 17 patients with CBD and 23 with PSP. Patients with CBD had frontoparietal atrophy on NMR associated with asymmetric akinetic-rigid syndrome, while PSP patients showed mesencephalic and superior collicular atrophy with T2 signal hyperintensity in the periacqueductal region associated with a parkinsonian syndrome and oculomotor and early balance disturbances. Myoclonus was only present in CBD. Cognitive examination revealed that apraxia and visuo-motor impairment was prevalent in CBD while greater impairment in executive functions was evident in PSP. In the light of these findings the most important features for differential diagnosis of these two disorders are discussed.

Original languageEnglish
Pages (from-to)19
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
Publication statusPublished - 1997

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Monza, D., Souveri, P., Fetoni, V., Testa, D., Genitrini, S., Grisoli, M., Savoiardo, M., Radice, D., Caraceni, T., & Girotti, F. (1997). Motor, cognitive and MRI aspects of corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP). Italian Journal of Neurological Sciences, 18(4), 19.