Motor cortex changes in a patient with hemicerebellectomy

V. Di Lazzaro, D. Restuccia, R. Nardone, M. G. Leggio, A. Oliviero, P. Profice, P. Tonali, M. Molinari

Research output: Contribution to journalArticlepeer-review

Abstract

To evaluate reorganisation of motor pathways following a cerebellar lesion, we studied motor cortex excitatory responses and inhibitory effects after transcranial stimulation, togethher with segmental spinal cord excitability, in one patient who had undergone hemicerebellectomy. We compared the results obtained using differe forms of stimulation capable of activating the cortico-spinal tract at differennt sites. Results were compared between sides. We previously reported that the threshold for responses is higher in the motor cortex contralateral to the impaired hemicerebellum and the right/left threshold asymmetry is clearly greater than normal when a circular coil centred over the vertex is used. In the present study, using electrical anodal stimulation, no side difference was observed. Significant interside differences were absent also when the durations of the silent periods or the mean amplitude of the flexor carpi radialis H reflex between the two sides were compared. The outcome is that the interside differences previously observed are mainly due to reduction in the intrinsic excitability properties of the motor cortex functionally related to the impaired hemicerebellum and not to modification of the ihnibitory properties of the cortex or to spinal mechanisms.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalElectroencephalography and Clinical Neurophysiology - Electromyography and Motor Control
Volume97
Issue number5
DOIs
Publication statusPublished - 1995

Keywords

  • Cerebellum
  • Electrical stimulation
  • Magnetic stimulationn
  • Motor cortex

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Motor cortex changes in a patient with hemicerebellectomy'. Together they form a unique fingerprint.

Cite this