Motor cortex changes in spinal cord injury: A TMS study

Eleonora Saturno, Claudio Bonato, Carlo Miniussi, Vincenzodi Lazzaro, Leonardo Callea

Research output: Contribution to journalArticlepeer-review


Using paired pulse transcranial magnetic stimulation (TMS) paradigms, we studied cortical excitability in a patient with spinal cord lesion. During posterior tibial nerve stimulation, the contextual flexion of hand fingers contralateral to the stimulated lower limb had suggested a change in motor cortex excitability. Results showed a decrease in the activity of motor cortex inhibitory circuits. This could suggest that in spinal cord injury, just as in stroke and peripheral deafferentation, a disinhibition of latent synapses within the motor cortex and the rewriting of a new motor map can occur.

Original languageEnglish
Pages (from-to)1084-1085
Number of pages2
JournalNeurological Research
Issue number10
Publication statusPublished - Dec 2008


  • Motor cortex plasticity
  • Spinal cord lesion
  • TMS

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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