Motor cortex excitability in Alzheimer's disease and in subcortical ischemic vascular dementia

Giovanna Alagona, Raffaele Ferri, Giovanni Pennisi, Anna Carnemolla, Tiziana Maci, Elisabetta Domina, Alain Maertens De Noordhout, Rita Bella

Research output: Contribution to journalArticlepeer-review

Abstract

Twenty Alzheimer's disease (AD) patients, 20 subcortical ischemic vascular dementia (SIVD) patients and 20 neurologically and cognitively normal subjects underwent transcranial magnetic stimulation to study motor cortex excitability changes. Motor threshold (MT), amplitude of motor evoked potentials, silent period and the H/M ratio (amplitude of maximal Hoffman reflex vs. that of maximal motor response) were considered. MT was lower in SIVD patients when compared with AD patients (P=0.003) and the control group (P

Original languageEnglish
Pages (from-to)95-98
Number of pages4
JournalNeuroscience Letters
Volume362
Issue number2
DOIs
Publication statusPublished - May 20 2004

Keywords

  • Alzheimer's disease
  • Motor cortex excitability
  • Subcortical ischemic vascular dementia
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Neuroscience(all)

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