Abstract
Objectives: To investigate motor disinhibition in affected and unaffected motor areas in the acute stage after stroke and during the early period of recovery. Methods: Fifteen patients with moderate to severe hemiparesis after acute unilateral stroke were compared with 10 healthy age-matched controls. We used paired transcranial magnetic stimulation to study intracortical inhibition and facilitation from the thenar eminence muscles on both sides. F-wave from the median nerve on both sides were recorded. The recordings were performed 5-7 days (T1) and 30 days after stroke. Results: In 10 patients who showed the presence of reliable motor evoked potentials on the affected side, intracortical inhibition was significantly reduced. On the unaffected side intracortical inhibition (ICI) was significantly reduced in all patients. Patients who presented significant motor recovery after 30 days showed persistence of abnormal disinhibition in the affected hemisphere but a return to normal ICI in the unaffected hemisphere. Patients with poor motor recovery showed persistence of abnormal disinhibition on both sides. No significant changes were observed in F-wave amplitude. Conclusions: Motor disinhibition occurs on both sides after stroke in all acute stage patients. Changes in motor disinhibition on unaffected side also are related to motor recovery.
| Original language | English |
|---|---|
| Pages (from-to) | 936-943 |
| Number of pages | 8 |
| Journal | Clinical Neurophysiology |
| Volume | 113 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Motor recovery
- Plasticity
- Rehabilitation
- Stroke
- Transcranial magnetic stimulation
ASJC Scopus subject areas
- Clinical Neurology
- Radiology Nuclear Medicine and imaging
- Neurology
- Sensory Systems
- Physiology (medical)
Cite this
Motor disinhibition in affected and unaffected hemisphere in the early period of recovery after stroke. / Manganotti, P.; Patuzzo, S.; Cortese, F.; Palermo, A.; Smania, N.; Fiaschi, A.
In: Clinical Neurophysiology, Vol. 113, No. 6, 2002, p. 936-943.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Motor disinhibition in affected and unaffected hemisphere in the early period of recovery after stroke
AU - Manganotti, P.
AU - Patuzzo, S.
AU - Cortese, F.
AU - Palermo, A.
AU - Smania, N.
AU - Fiaschi, A.
PY - 2002
Y1 - 2002
N2 - Objectives: To investigate motor disinhibition in affected and unaffected motor areas in the acute stage after stroke and during the early period of recovery. Methods: Fifteen patients with moderate to severe hemiparesis after acute unilateral stroke were compared with 10 healthy age-matched controls. We used paired transcranial magnetic stimulation to study intracortical inhibition and facilitation from the thenar eminence muscles on both sides. F-wave from the median nerve on both sides were recorded. The recordings were performed 5-7 days (T1) and 30 days after stroke. Results: In 10 patients who showed the presence of reliable motor evoked potentials on the affected side, intracortical inhibition was significantly reduced. On the unaffected side intracortical inhibition (ICI) was significantly reduced in all patients. Patients who presented significant motor recovery after 30 days showed persistence of abnormal disinhibition in the affected hemisphere but a return to normal ICI in the unaffected hemisphere. Patients with poor motor recovery showed persistence of abnormal disinhibition on both sides. No significant changes were observed in F-wave amplitude. Conclusions: Motor disinhibition occurs on both sides after stroke in all acute stage patients. Changes in motor disinhibition on unaffected side also are related to motor recovery.
AB - Objectives: To investigate motor disinhibition in affected and unaffected motor areas in the acute stage after stroke and during the early period of recovery. Methods: Fifteen patients with moderate to severe hemiparesis after acute unilateral stroke were compared with 10 healthy age-matched controls. We used paired transcranial magnetic stimulation to study intracortical inhibition and facilitation from the thenar eminence muscles on both sides. F-wave from the median nerve on both sides were recorded. The recordings were performed 5-7 days (T1) and 30 days after stroke. Results: In 10 patients who showed the presence of reliable motor evoked potentials on the affected side, intracortical inhibition was significantly reduced. On the unaffected side intracortical inhibition (ICI) was significantly reduced in all patients. Patients who presented significant motor recovery after 30 days showed persistence of abnormal disinhibition in the affected hemisphere but a return to normal ICI in the unaffected hemisphere. Patients with poor motor recovery showed persistence of abnormal disinhibition on both sides. No significant changes were observed in F-wave amplitude. Conclusions: Motor disinhibition occurs on both sides after stroke in all acute stage patients. Changes in motor disinhibition on unaffected side also are related to motor recovery.
KW - Motor recovery
KW - Plasticity
KW - Rehabilitation
KW - Stroke
KW - Transcranial magnetic stimulation
UR - http://www.scopus.com/inward/record.url?scp=0036275627&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036275627&partnerID=8YFLogxK
U2 - 10.1016/S1388-2457(02)00062-7
DO - 10.1016/S1388-2457(02)00062-7
M3 - Article
C2 - 12048054
AN - SCOPUS:0036275627
VL - 113
SP - 936
EP - 943
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 6
ER -