Motor disinhibition in affected and unaffected hemisphere in the early period of recovery after stroke

P. Manganotti, S. Patuzzo, F. Cortese, A. Palermo, N. Smania, A. Fiaschi

Research output: Contribution to journalArticle

190 Citations (Scopus)

Abstract

Objectives: To investigate motor disinhibition in affected and unaffected motor areas in the acute stage after stroke and during the early period of recovery. Methods: Fifteen patients with moderate to severe hemiparesis after acute unilateral stroke were compared with 10 healthy age-matched controls. We used paired transcranial magnetic stimulation to study intracortical inhibition and facilitation from the thenar eminence muscles on both sides. F-wave from the median nerve on both sides were recorded. The recordings were performed 5-7 days (T1) and 30 days after stroke. Results: In 10 patients who showed the presence of reliable motor evoked potentials on the affected side, intracortical inhibition was significantly reduced. On the unaffected side intracortical inhibition (ICI) was significantly reduced in all patients. Patients who presented significant motor recovery after 30 days showed persistence of abnormal disinhibition in the affected hemisphere but a return to normal ICI in the unaffected hemisphere. Patients with poor motor recovery showed persistence of abnormal disinhibition on both sides. No significant changes were observed in F-wave amplitude. Conclusions: Motor disinhibition occurs on both sides after stroke in all acute stage patients. Changes in motor disinhibition on unaffected side also are related to motor recovery.

Original languageEnglish
Pages (from-to)936-943
Number of pages8
JournalClinical Neurophysiology
Volume113
Issue number6
DOIs
Publication statusPublished - 2002

Fingerprint

Stroke
Motor Evoked Potentials
Transcranial Magnetic Stimulation
Median Nerve
Motor Cortex
Paresis
Muscles

Keywords

  • Motor recovery
  • Plasticity
  • Rehabilitation
  • Stroke
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

Cite this

Motor disinhibition in affected and unaffected hemisphere in the early period of recovery after stroke. / Manganotti, P.; Patuzzo, S.; Cortese, F.; Palermo, A.; Smania, N.; Fiaschi, A.

In: Clinical Neurophysiology, Vol. 113, No. 6, 2002, p. 936-943.

Research output: Contribution to journalArticle

Manganotti, P, Patuzzo, S, Cortese, F, Palermo, A, Smania, N & Fiaschi, A 2002, 'Motor disinhibition in affected and unaffected hemisphere in the early period of recovery after stroke', Clinical Neurophysiology, vol. 113, no. 6, pp. 936-943. https://doi.org/10.1016/S1388-2457(02)00062-7
Manganotti, P. ; Patuzzo, S. ; Cortese, F. ; Palermo, A. ; Smania, N. ; Fiaschi, A. / Motor disinhibition in affected and unaffected hemisphere in the early period of recovery after stroke. In: Clinical Neurophysiology. 2002 ; Vol. 113, No. 6. pp. 936-943.
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