Motor evoked potentials in a mouse model of chronic multiple sclerosis

Stefano Amadio, Stefano Pluchino, Elena Brini, Paolo Morana, Roberta Guerriero, Filippo Martinelli Boneschi, Giancarlo Comi, Paola Zaratin, Valeria Muzio, Ubaldo Del Carro

Research output: Contribution to journalArticle

Abstract

We tested cortical motor evoked potentials (cMEPs) as a quantitative marker for in vivo monitoring of corticospinal tract damage in a murine multiple sclerosis model (experimental autoimmune encephalomyelitis, EAE). The cMEPs, previously standardized in naive C57BL76 developing and adult mice, were studied longitudinally in adult EAE mice. Central conduction times (CCTs) increased significantly shortly before the earliest clinical signs developed (10 days postimmunization, dpi), with peak delay in acute EAE (20-40 dpi). In clinically stable disease (80 dpi), CCTs did not increase further, but cMEP amplitude declined progressively, with complete loss in >80% of mice at 120 dpi. Increase in CCT correlated with presence of inflammatory infiltrates and demyelination in acute EAE, whereas small or absent cMEPs were associated with continuing axonal damage in clinically-stabilized disease and beyond (>80 dpi). These results demonstrate that cMEPs are a useful method for monitoring corticospinal tract function in chronic-progressive EAE, and provide insight into the pathological substrate of the condition.

Original languageEnglish
Pages (from-to)265-273
Number of pages9
JournalMuscle and Nerve
Volume33
Issue number2
DOIs
Publication statusPublished - Feb 2006

Keywords

  • Axonal degeneration
  • Demyelination
  • Experimental autoimmune encephalomyelitis
  • Motor evoked potentials
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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  • Cite this

    Amadio, S., Pluchino, S., Brini, E., Morana, P., Guerriero, R., Boneschi, F. M., Comi, G., Zaratin, P., Muzio, V., & Del Carro, U. (2006). Motor evoked potentials in a mouse model of chronic multiple sclerosis. Muscle and Nerve, 33(2), 265-273. https://doi.org/10.1002/mus.20463