Motor nerve biopsy studies in motor neuropathy and motor neuron disease

Massimo Corbo, M. Kamel Abouzahr, Norman Latov, Sandro Iannaccone, Angelo Quattrini, Raffaello Nemni, Nicola Canal, Arthur P. Hays

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The clinical presentation of motor neuropathy often resembles that of motor neuron disease, sometimes leading to an erroneous diagnosis. Moreover, the underlying pathological process in motor neuropathy has been rarely investigated and there are no systematic studies of the affected motor nerves. We describe a new motor nerve biopsy procedure, performed in 15 patients: 6 with motor neuropathy and 9 with motor neuron disease. The motor branch from the anterior division of the obturator nerve to the gracilis muscle in the thigh was biopsied. In both groups of patients the motor nerves exhibited depletion of myelinated nerve fibers. In motor neuropathy there was a significantly higher density of regenerative clusters of small myelinated fibers in comparison to motor nerves from patients with motor neuron disease. In addition, in 3 patients with motor neuropathy there was evidence for demyelination with thinly myelinated axons and small onion bulb formations. These pathological studies of motor nerve biopsies can help to differentiate motor neuropathy from motor neuron disease.

Original languageEnglish
Pages (from-to)15-21
Number of pages7
JournalMuscle and Nerve
Volume20
Issue number1
DOIs
Publication statusPublished - 1997

Fingerprint

Motor Neuron Disease
Biopsy
Obturator Nerve
Myelinated Nerve Fibers
Onions
Demyelinating Diseases
Pathologic Processes
Thigh
Axons

Keywords

  • amyotrophic lateral sclerosis
  • anti-GM1 antibodies
  • motor neuron disease
  • motor neuropathy
  • nerve biopsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Motor nerve biopsy studies in motor neuropathy and motor neuron disease. / Corbo, Massimo; Abouzahr, M. Kamel; Latov, Norman; Iannaccone, Sandro; Quattrini, Angelo; Nemni, Raffaello; Canal, Nicola; Hays, Arthur P.

In: Muscle and Nerve, Vol. 20, No. 1, 1997, p. 15-21.

Research output: Contribution to journalArticle

Corbo, Massimo ; Abouzahr, M. Kamel ; Latov, Norman ; Iannaccone, Sandro ; Quattrini, Angelo ; Nemni, Raffaello ; Canal, Nicola ; Hays, Arthur P. / Motor nerve biopsy studies in motor neuropathy and motor neuron disease. In: Muscle and Nerve. 1997 ; Vol. 20, No. 1. pp. 15-21.
@article{025a3d59a116488d996fa72c524d9474,
title = "Motor nerve biopsy studies in motor neuropathy and motor neuron disease",
abstract = "The clinical presentation of motor neuropathy often resembles that of motor neuron disease, sometimes leading to an erroneous diagnosis. Moreover, the underlying pathological process in motor neuropathy has been rarely investigated and there are no systematic studies of the affected motor nerves. We describe a new motor nerve biopsy procedure, performed in 15 patients: 6 with motor neuropathy and 9 with motor neuron disease. The motor branch from the anterior division of the obturator nerve to the gracilis muscle in the thigh was biopsied. In both groups of patients the motor nerves exhibited depletion of myelinated nerve fibers. In motor neuropathy there was a significantly higher density of regenerative clusters of small myelinated fibers in comparison to motor nerves from patients with motor neuron disease. In addition, in 3 patients with motor neuropathy there was evidence for demyelination with thinly myelinated axons and small onion bulb formations. These pathological studies of motor nerve biopsies can help to differentiate motor neuropathy from motor neuron disease.",
keywords = "amyotrophic lateral sclerosis, anti-GM1 antibodies, motor neuron disease, motor neuropathy, nerve biopsy",
author = "Massimo Corbo and Abouzahr, {M. Kamel} and Norman Latov and Sandro Iannaccone and Angelo Quattrini and Raffaello Nemni and Nicola Canal and Hays, {Arthur P.}",
year = "1997",
doi = "10.1002/(SICI)1097-4598(199701)20:1<15::AID-MUS2>3.0.CO;2-K",
language = "English",
volume = "20",
pages = "15--21",
journal = "Muscle and Nerve",
issn = "0148-639X",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - Motor nerve biopsy studies in motor neuropathy and motor neuron disease

AU - Corbo, Massimo

AU - Abouzahr, M. Kamel

AU - Latov, Norman

AU - Iannaccone, Sandro

AU - Quattrini, Angelo

AU - Nemni, Raffaello

AU - Canal, Nicola

AU - Hays, Arthur P.

PY - 1997

Y1 - 1997

N2 - The clinical presentation of motor neuropathy often resembles that of motor neuron disease, sometimes leading to an erroneous diagnosis. Moreover, the underlying pathological process in motor neuropathy has been rarely investigated and there are no systematic studies of the affected motor nerves. We describe a new motor nerve biopsy procedure, performed in 15 patients: 6 with motor neuropathy and 9 with motor neuron disease. The motor branch from the anterior division of the obturator nerve to the gracilis muscle in the thigh was biopsied. In both groups of patients the motor nerves exhibited depletion of myelinated nerve fibers. In motor neuropathy there was a significantly higher density of regenerative clusters of small myelinated fibers in comparison to motor nerves from patients with motor neuron disease. In addition, in 3 patients with motor neuropathy there was evidence for demyelination with thinly myelinated axons and small onion bulb formations. These pathological studies of motor nerve biopsies can help to differentiate motor neuropathy from motor neuron disease.

AB - The clinical presentation of motor neuropathy often resembles that of motor neuron disease, sometimes leading to an erroneous diagnosis. Moreover, the underlying pathological process in motor neuropathy has been rarely investigated and there are no systematic studies of the affected motor nerves. We describe a new motor nerve biopsy procedure, performed in 15 patients: 6 with motor neuropathy and 9 with motor neuron disease. The motor branch from the anterior division of the obturator nerve to the gracilis muscle in the thigh was biopsied. In both groups of patients the motor nerves exhibited depletion of myelinated nerve fibers. In motor neuropathy there was a significantly higher density of regenerative clusters of small myelinated fibers in comparison to motor nerves from patients with motor neuron disease. In addition, in 3 patients with motor neuropathy there was evidence for demyelination with thinly myelinated axons and small onion bulb formations. These pathological studies of motor nerve biopsies can help to differentiate motor neuropathy from motor neuron disease.

KW - amyotrophic lateral sclerosis

KW - anti-GM1 antibodies

KW - motor neuron disease

KW - motor neuropathy

KW - nerve biopsy

UR - http://www.scopus.com/inward/record.url?scp=0031015010&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031015010&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1097-4598(199701)20:1<15::AID-MUS2>3.0.CO;2-K

DO - 10.1002/(SICI)1097-4598(199701)20:1<15::AID-MUS2>3.0.CO;2-K

M3 - Article

VL - 20

SP - 15

EP - 21

JO - Muscle and Nerve

JF - Muscle and Nerve

SN - 0148-639X

IS - 1

ER -