Motor neuron disease in a patient with a monoclonal IgMk directed against GM1, GD1b, and high-molecular-weight neural-specific glycoproteins

E. Nobile-Orazio, G. Legname, R. Daverio, M. Carpo, A. Giuliani, S. Sonnino, G. Scarlato

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

In a patient with motor neuron disease and benign IgMk monoclonal gammopathy, the M protein reacted with the glycolipids GM1, GD1b, and asialo GM1 and, by immunoblot, with some high-molecular-weight neural-specific glycoproteins. The main reactive bands had an approximate molecular weight of 250 and 400 kd, were most concentrated in the spinal cord, and were also bound by the lectin peanut agglutinin. The presence of the Ga1(β1-3)Ga1NAc epitope on these neural-specific glycoproteins may help to explain the selective neurological impairment of the patient.

Original languageEnglish
Pages (from-to)190-194
Number of pages5
JournalAnnals of Neurology
Volume28
Issue number2
DOIs
Publication statusPublished - 1990

Fingerprint

Motor Neuron Disease
Glycoproteins
Molecular Weight
Monoclonal Gammopathy of Undetermined Significance
Peanut Agglutinin
Glycolipids
Lectins
Epitopes
Spinal Cord
Proteins
asialo GM1 ganglioside

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Motor neuron disease in a patient with a monoclonal IgMk directed against GM1, GD1b, and high-molecular-weight neural-specific glycoproteins. / Nobile-Orazio, E.; Legname, G.; Daverio, R.; Carpo, M.; Giuliani, A.; Sonnino, S.; Scarlato, G.

In: Annals of Neurology, Vol. 28, No. 2, 1990, p. 190-194.

Research output: Contribution to journalArticle

Nobile-Orazio, E. ; Legname, G. ; Daverio, R. ; Carpo, M. ; Giuliani, A. ; Sonnino, S. ; Scarlato, G. / Motor neuron disease in a patient with a monoclonal IgMk directed against GM1, GD1b, and high-molecular-weight neural-specific glycoproteins. In: Annals of Neurology. 1990 ; Vol. 28, No. 2. pp. 190-194.
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