Motor overactivity and loss of motor circadian rhythm in fatal familial insomnia: An actigraphic study

Giuseppe Plazzi, Yves Schutz, Pietro Cortelli, Federica Provini, Patrizia Avoni, Erika Heikkila, Paolo Tinuper, Laura Solieri, Elio Lugaresi, Pasquale Montagna

Research output: Contribution to journalArticle

Abstract

The 24-hour rest-activity pattern and the amount of motor activity was studied in a patient with fatal familial insomnia (FFI) by means of wrist actigraphy. During the study, the patient underwent indirect calorimetry. The 52-day recording showed severe disruption of the 24-hour rest-activity pattern with increased motor activity up to 80%. The 24-hour energy expenditure, assayed in a respiration chamber, was strikingly elevated by 60%. Chronic motor overactivity and loss of circadian rest-activity rhythm may play a role in the progressive metabolic exhaustion leading to death in FFI patients.

Original languageEnglish
Pages (from-to)739-742
Number of pages4
JournalSleep
Volume20
Issue number9
Publication statusPublished - 1997

Keywords

  • Actigraphy
  • Fatal familial insomnia
  • Indirect calorimetry
  • Motor circadian rhythm

ASJC Scopus subject areas

  • Physiology

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