Motor pattern of periodic limb movements during sleep

F. Provini, R. Vetrugno, S. Meletti, G. Plazzi, L. Solieri, E. Lugaresi, G. Coccagna, P. Montagna

Research output: Contribution to journalArticle

Abstract

Background: The pathophysiology of periodic limb movements in sleep (PLMS) in restless legs syndrome (RLS) is unclear. Objective: The authors neurophysiologically investigated PLMS in patients with idiopathic RLS in order to obtain information on the origin and pathophysiology of the movements. Methods: Ten patients with idiopathic RLS underwent electromyography with nerve conduction velocity (EMG-CV), somatosensory evoked potentials (SEPs), transcranial magnetic stimulation (TMS), nocturnal videopolysomnography, and multiple sleep latency test. The authors analyzed 100 consecutive PLMS for each patient to determine how frequently each muscle was involved in the PLMS; how frequently EMG activity started in a given muscle; and the time delay and pattern of activation between the first and the other activated muscles. Results: EMG-CV, SEPs, and TMS findings were all normal; in PLMS, leg muscles were those more frequently involved, often with alternation of side. Axial muscles were rarely and upper limb muscles sometimes involved. The tibialis anterior was the most frequent starting muscle. There was no constant recruitment pattern from one PLMS episode to another, even in the same patient. There was no ordinate caudal or rostral spread of the EMG activity. Conclusion: The recruitment pattern indicates the engagement of different, independent, and sometimes unsynchronized generators for each PLMS. The authors hypothesize an abnormal hyperexcitability along the entire spinal cord, especially its lumbosacral and cervical segments, as the primary cause of PLMS, triggered by sleep-related factors located at a supraspinal but still unresolved level.

Original languageEnglish
Pages (from-to)300-304
Number of pages5
JournalNeurology
Volume57
Issue number2
Publication statusPublished - Jul 24 2001

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Sleep
Extremities
Muscles
Restless Legs Syndrome
Somatosensory Evoked Potentials
Transcranial Magnetic Stimulation
Neural Conduction
Electromyography
Upper Extremity
Leg
Spinal Cord

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Provini, F., Vetrugno, R., Meletti, S., Plazzi, G., Solieri, L., Lugaresi, E., ... Montagna, P. (2001). Motor pattern of periodic limb movements during sleep. Neurology, 57(2), 300-304.

Motor pattern of periodic limb movements during sleep. / Provini, F.; Vetrugno, R.; Meletti, S.; Plazzi, G.; Solieri, L.; Lugaresi, E.; Coccagna, G.; Montagna, P.

In: Neurology, Vol. 57, No. 2, 24.07.2001, p. 300-304.

Research output: Contribution to journalArticle

Provini, F, Vetrugno, R, Meletti, S, Plazzi, G, Solieri, L, Lugaresi, E, Coccagna, G & Montagna, P 2001, 'Motor pattern of periodic limb movements during sleep', Neurology, vol. 57, no. 2, pp. 300-304.
Provini F, Vetrugno R, Meletti S, Plazzi G, Solieri L, Lugaresi E et al. Motor pattern of periodic limb movements during sleep. Neurology. 2001 Jul 24;57(2):300-304.
Provini, F. ; Vetrugno, R. ; Meletti, S. ; Plazzi, G. ; Solieri, L. ; Lugaresi, E. ; Coccagna, G. ; Montagna, P. / Motor pattern of periodic limb movements during sleep. In: Neurology. 2001 ; Vol. 57, No. 2. pp. 300-304.
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