Motor practice promotes increased activity in brain regions structurally disconnected after subcortical stroke

Rosemary A. Bosnell, Tamas Kincses, Charlotte J. Stagg, Valentina Tomassini, Udo Kischka, Saad Jbabdi, Mark W. Woolrich, Jesper Andersson, Paul M. Matthews, Heidi Johansen-Berg

Research output: Contribution to journalArticle

Abstract

Background. Motor practice is an important component of neurorehabilitation. Imaging studies in healthy individuals show that dynamic brain activation changes with practice. Defining patterns of functional brain plasticity associated with motor practice following stroke could guide rehabilitation. Objective. The authors aimed to test whether practice-related changes in brain activity differ after stroke and to explore spatial relationships between activity changes and patterns of structural degeneration. Methods. They studied 10 patients at least 6 months after left-hemisphere subcortical strokes and 18 healthy controls. Diffusion-weighted magnetic resonance imaging (MRI) was acquired at baseline, and functional MRI (fMRI) was acquired during performance of a visuomotor tracking task before and after a 15-day period of practice of the same task. Results. Smaller short-term practice effects at baseline correlated with lower fractional anisotropy in the posterior limbs of the internal capsule (PLIC) bilaterally in patients (t > 3; cluster P 2.3; cluster P

Original languageEnglish
Pages (from-to)607-616
Number of pages10
JournalNeurorehabilitation and Neural Repair
Volume25
Issue number7
DOIs
Publication statusPublished - Sep 2011

Keywords

  • diffusion
  • fMRI
  • motor control
  • motor practice
  • MRI
  • rehabilitation
  • stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Rehabilitation
  • Neurology

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    Bosnell, R. A., Kincses, T., Stagg, C. J., Tomassini, V., Kischka, U., Jbabdi, S., Woolrich, M. W., Andersson, J., Matthews, P. M., & Johansen-Berg, H. (2011). Motor practice promotes increased activity in brain regions structurally disconnected after subcortical stroke. Neurorehabilitation and Neural Repair, 25(7), 607-616. https://doi.org/10.1177/1545968311405675