Motor recovery after early brain damage; a case of brain plasticity

Umberto Sabatini, Danilo Toni, Patrizia Pantano, Giorgio Brughitta, Alessandro Padovani, Luigi Bozzao, Gian Luigi Lenzi

Research output: Contribution to journalArticlepeer-review


Background Motor recovery is remarkable when the brain is damaged early in life. We describe a case of early damage to the right hemisphere with remarkable reorganization and plastic functional changes, studied by computed Neurolmaging. QueDescriptionA 31-year-old man had a left-sided hemi-plegia at the age of 12, followed by good motor recovery despite a large right cortical-subcortical lesion. Single-photon emission computed tomography with motor activation study showed cerebral blood flow increase in the left premotor and sensorimotor cortices irrespective of the hand he was moving, without flow changes in the right hemisphere. ConclusionsA remarkable reorganization and plastic brain functional changes occurred in a patient after early diffuse damage of the right hemisphere. The study points to a potential role of ipsilateral cortical efferent pathways in subserving hand movements after early cerebral damage. (Stroke. 1994;25:514-517.).

Original languageEnglish
Pages (from-to)514-517
Number of pages4
Issue number2
Publication statusPublished - 1994


  • Emission computed
  • Motor activity
  • Tomography
  • Tomography
  • X-ray computed
  • Young adults

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing
  • Neuroscience(all)


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