Motor Responses to Afferent Stimulation in Juvenile Myoclonic Epilepsy

Paolo Manganotti, Stefano Tamburin, Luigi Giuseppe Bongiovanni, Giampietro Zanette, Antonio Fiaschi

Research output: Contribution to journalArticlepeer-review


Purpose: To document whether the mechanisms responsible for myoclonic jerks in juvenile myoclonic epilepsy (JME) are similar to those causing other forms of myoclonus. Methods: We studied somatosensory evoked potentials, the conditioning effect of cutaneous afferents on motor potentials evoked by transcranial magnetic stimulation (TMS), and intracortical inhibition and facilitation in response to paired TMS in a group of nine patients with JME and 20 normal controls. Results: Intracortical inhibition was abnormal, whereas cortical somatosensory evoked potentials and TMS conditioned by cutaneous afferents were unaltered in JME patients. Conclusions: Abnormal processing of cutaneous afferents would not appear to contribute to myoclonus in JME.

Original languageEnglish
Pages (from-to)77-80
Number of pages4
Issue number1
Publication statusPublished - Jan 2004


  • Cortical myoclonus
  • Janz syndrome
  • Juvenile myoclonic epilepsy
  • Sensorimotor integration
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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