Motor Responses to Afferent Stimulation in Juvenile Myoclonic Epilepsy

Paolo Manganotti, Stefano Tamburin, Luigi Giuseppe Bongiovanni, Giampietro Zanette, Antonio Fiaschi

Research output: Contribution to journalArticle

Abstract

Purpose: To document whether the mechanisms responsible for myoclonic jerks in juvenile myoclonic epilepsy (JME) are similar to those causing other forms of myoclonus. Methods: We studied somatosensory evoked potentials, the conditioning effect of cutaneous afferents on motor potentials evoked by transcranial magnetic stimulation (TMS), and intracortical inhibition and facilitation in response to paired TMS in a group of nine patients with JME and 20 normal controls. Results: Intracortical inhibition was abnormal, whereas cortical somatosensory evoked potentials and TMS conditioned by cutaneous afferents were unaltered in JME patients. Conclusions: Abnormal processing of cutaneous afferents would not appear to contribute to myoclonus in JME.

Original languageEnglish
Pages (from-to)77-80
Number of pages4
JournalEpilepsia
Volume45
Issue number1
DOIs
Publication statusPublished - Jan 2004

Fingerprint

Juvenile Myoclonic Epilepsy
Myoclonus
Transcranial Magnetic Stimulation
Somatosensory Evoked Potentials
Skin
Motor Evoked Potentials

Keywords

  • Cortical myoclonus
  • Janz syndrome
  • Juvenile myoclonic epilepsy
  • Sensorimotor integration
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Manganotti, P., Tamburin, S., Bongiovanni, L. G., Zanette, G., & Fiaschi, A. (2004). Motor Responses to Afferent Stimulation in Juvenile Myoclonic Epilepsy. Epilepsia, 45(1), 77-80. https://doi.org/10.1111/j.0013-9580.2004.21003.x

Motor Responses to Afferent Stimulation in Juvenile Myoclonic Epilepsy. / Manganotti, Paolo; Tamburin, Stefano; Bongiovanni, Luigi Giuseppe; Zanette, Giampietro; Fiaschi, Antonio.

In: Epilepsia, Vol. 45, No. 1, 01.2004, p. 77-80.

Research output: Contribution to journalArticle

Manganotti, P, Tamburin, S, Bongiovanni, LG, Zanette, G & Fiaschi, A 2004, 'Motor Responses to Afferent Stimulation in Juvenile Myoclonic Epilepsy', Epilepsia, vol. 45, no. 1, pp. 77-80. https://doi.org/10.1111/j.0013-9580.2004.21003.x
Manganotti P, Tamburin S, Bongiovanni LG, Zanette G, Fiaschi A. Motor Responses to Afferent Stimulation in Juvenile Myoclonic Epilepsy. Epilepsia. 2004 Jan;45(1):77-80. https://doi.org/10.1111/j.0013-9580.2004.21003.x
Manganotti, Paolo ; Tamburin, Stefano ; Bongiovanni, Luigi Giuseppe ; Zanette, Giampietro ; Fiaschi, Antonio. / Motor Responses to Afferent Stimulation in Juvenile Myoclonic Epilepsy. In: Epilepsia. 2004 ; Vol. 45, No. 1. pp. 77-80.
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