TY - JOUR
T1 - MouBeAT: A new and open toolbox for guided analysis of behavioral tests in mice
AU - Bello-Arroyo, E
AU - Roque, H
AU - Marcos, A
AU - Orihuel, J
AU - Higuera-Matas, A
AU - Desco, M
AU - Caiolfa, VR
AU - Ambrosio, E
AU - Lara-Pezzi, E
AU - Gómez-Gaviro, MV
PY - 2018
Y1 - 2018
N2 - Animal behavioral tests are essential to understand the bases of neurologic and psychological disorders, which can be evaluated by different methodological and experimental models. However, the quantification of behavioral tests results is limited by the considerable amount of time needed for manual evaluation and the high costs of automated analysis software. To overcome these limitations, we describe here a new, open source toolbox for ImageJ, called Mouse Behavioral Analysis Toolbox (MouBeAT), designed to analyze different behavioral tests in rodents semi-automatically. These tests include Open Field (OF), Elevated Plus Maze (EPM), Y-maze (YM) test and Morris Water Maze (MWM). MouBeAT showed a high correlation with manual evaluation in all the parameters analyzed for all the behavioral tests, reinforcing its value as an accurate analysis tool. This new tool is freely available online. © 2018 Bello-Arroyo, Roque, Marcos, Orihuel, Higuera-Matas, Desco, Caiolfa, Ambrosio, Lara-Pezzi and Gómez-Gaviro.
AB - Animal behavioral tests are essential to understand the bases of neurologic and psychological disorders, which can be evaluated by different methodological and experimental models. However, the quantification of behavioral tests results is limited by the considerable amount of time needed for manual evaluation and the high costs of automated analysis software. To overcome these limitations, we describe here a new, open source toolbox for ImageJ, called Mouse Behavioral Analysis Toolbox (MouBeAT), designed to analyze different behavioral tests in rodents semi-automatically. These tests include Open Field (OF), Elevated Plus Maze (EPM), Y-maze (YM) test and Morris Water Maze (MWM). MouBeAT showed a high correlation with manual evaluation in all the parameters analyzed for all the behavioral tests, reinforcing its value as an accurate analysis tool. This new tool is freely available online. © 2018 Bello-Arroyo, Roque, Marcos, Orihuel, Higuera-Matas, Desco, Caiolfa, Ambrosio, Lara-Pezzi and Gómez-Gaviro.
U2 - 10.3389/fnbeh.2018.00201
DO - 10.3389/fnbeh.2018.00201
M3 - Article
VL - 12
JO - Frontiers in Behavioral Neuroscience
JF - Frontiers in Behavioral Neuroscience
SN - 1662-5153
M1 - 201
ER -