Abstract
Precisely targeted genetic manipulation of the laboratory mouse has been one of the most significant achievements in the field of modeling human genetic diseases. The availability of an ever-increasing number of mutants, and the ability of generating ever-more complex manipulations beyond the simple gene knockout, offer unprecedented possibilities for genetic experiments addressing complex questions. Thus, the mouse is getting closer and closer to the most powerful genetic models such as Drosophila. This chapter provides a view of the commonly used or most promising approaches to modeling genetic disease in the mouse. It also provides a discussion on which approach is more suited to modeling different types of mutations.
| Original language | English |
|---|---|
| Title of host publication | Vogel and Motulsky's Human Genetics: Problems and Approaches (Fourth Edition) |
| Publisher | Springer-Verlag Berlin Heidelberg |
| Pages | 779-785 |
| Number of pages | 7 |
| ISBN (Print) | 9783540376545, 9783540376538 |
| DOIs | |
| Publication status | Published - 2010 |
Fingerprint
ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Mouse as a model for human disease. / Baldini, Antonio.
Vogel and Motulsky's Human Genetics: Problems and Approaches (Fourth Edition). Springer-Verlag Berlin Heidelberg, 2010. p. 779-785.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Mouse as a model for human disease
AU - Baldini, Antonio
PY - 2010
Y1 - 2010
N2 - Precisely targeted genetic manipulation of the laboratory mouse has been one of the most significant achievements in the field of modeling human genetic diseases. The availability of an ever-increasing number of mutants, and the ability of generating ever-more complex manipulations beyond the simple gene knockout, offer unprecedented possibilities for genetic experiments addressing complex questions. Thus, the mouse is getting closer and closer to the most powerful genetic models such as Drosophila. This chapter provides a view of the commonly used or most promising approaches to modeling genetic disease in the mouse. It also provides a discussion on which approach is more suited to modeling different types of mutations.
AB - Precisely targeted genetic manipulation of the laboratory mouse has been one of the most significant achievements in the field of modeling human genetic diseases. The availability of an ever-increasing number of mutants, and the ability of generating ever-more complex manipulations beyond the simple gene knockout, offer unprecedented possibilities for genetic experiments addressing complex questions. Thus, the mouse is getting closer and closer to the most powerful genetic models such as Drosophila. This chapter provides a view of the commonly used or most promising approaches to modeling genetic disease in the mouse. It also provides a discussion on which approach is more suited to modeling different types of mutations.
UR - http://www.scopus.com/inward/record.url?scp=84920423832&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920423832&partnerID=8YFLogxK
U2 - 10.1007/978-3-540-37654-5_34
DO - 10.1007/978-3-540-37654-5_34
M3 - Chapter
SN - 9783540376545
SN - 9783540376538
SP - 779
EP - 785
BT - Vogel and Motulsky's Human Genetics: Problems and Approaches (Fourth Edition)
PB - Springer-Verlag Berlin Heidelberg
ER -