Mouse as a model for human disease

Antonio Baldini

doi:10.1007/978-3-540-37654-5_34

Mouse as a model for human disease

Antonio Baldini

www.neuromed.it

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Precisely targeted genetic manipulation of the laboratory mouse has been one of the most significant achievements in the field of modeling human genetic diseases. The availability of an ever-increasing number of mutants, and the ability of generating ever-more complex manipulations beyond the simple gene knockout, offer unprecedented possibilities for genetic experiments addressing complex questions. Thus, the mouse is getting closer and closer to the most powerful genetic models such as Drosophila. This chapter provides a view of the commonly used or most promising approaches to modeling genetic disease in the mouse. It also provides a discussion on which approach is more suited to modeling different types of mutations.

Original language	English
Title of host publication	Vogel and Motulsky's Human Genetics: Problems and Approaches (Fourth Edition)
Publisher	Springer-Verlag Berlin Heidelberg
Pages	779-785
Number of pages	7
ISBN (Print)	9783540376545, 9783540376538
DOIs	https://doi.org/10.1007/978-3-540-37654-5_34
Publication status	Published - 2010

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ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

Cite this

Baldini, A. (2010). Mouse as a model for human disease. In Vogel and Motulsky's Human Genetics: Problems and Approaches (Fourth Edition) (pp. 779-785). Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/978-3-540-37654-5_34

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Access to Document

10.1007/978-3-540-37654-5_34