TY - JOUR
T1 - Mouse hepatocytes lacking mGlu5 metabotropic glutamate receptors are less sensitive to hypoxic damage
AU - Storto, Marianna
AU - Battaglia, Giuseppe
AU - Gradini, Roberto
AU - Bruno, Valeria
AU - Nicoletti, Ferdinando
AU - Vairetti, Mariapia
PY - 2004/8/16
Y1 - 2004/8/16
N2 - Endogenous activation of type-5 metabotropic glutamate receptors contributes to the development of hypoxia-induced liver cell injury. We have strengthened this hypothesis using glutamate mGlu5 receptor knockout mice. Hepatocytes isolated from knockout mice were less sensitive to hypoxic cell damage than hepatocytes from wild-type mice as assessed by lactate dehydrogenase release and formation of reactive oxygen species. The mGlu5 receptor antagonist, 2-methyl-6-(phenylethynyl)pyridine (MPEP) also protect hepatocytes against hypoxic damage.
AB - Endogenous activation of type-5 metabotropic glutamate receptors contributes to the development of hypoxia-induced liver cell injury. We have strengthened this hypothesis using glutamate mGlu5 receptor knockout mice. Hepatocytes isolated from knockout mice were less sensitive to hypoxic cell damage than hepatocytes from wild-type mice as assessed by lactate dehydrogenase release and formation of reactive oxygen species. The mGlu5 receptor antagonist, 2-methyl-6-(phenylethynyl)pyridine (MPEP) also protect hepatocytes against hypoxic damage.
KW - Hypoxia
KW - mGlu5 knockout
KW - mouse
KW - Reactive oxygen species
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U2 - 10.1016/j.ejphar.2004.06.023
DO - 10.1016/j.ejphar.2004.06.023
M3 - Article
C2 - 15321731
AN - SCOPUS:4143056101
VL - 497
SP - 25
EP - 27
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -