Mouse hepatocytes lacking mGlu5 metabotropic glutamate receptors are less sensitive to hypoxic damage

Marianna Storto, Giuseppe Battaglia, Roberto Gradini, Valeria Bruno, Ferdinando Nicoletti, Mariapia Vairetti

Research output: Contribution to journalArticlepeer-review

Abstract

Endogenous activation of type-5 metabotropic glutamate receptors contributes to the development of hypoxia-induced liver cell injury. We have strengthened this hypothesis using glutamate mGlu5 receptor knockout mice. Hepatocytes isolated from knockout mice were less sensitive to hypoxic cell damage than hepatocytes from wild-type mice as assessed by lactate dehydrogenase release and formation of reactive oxygen species. The mGlu5 receptor antagonist, 2-methyl-6-(phenylethynyl)pyridine (MPEP) also protect hepatocytes against hypoxic damage.

Original languageEnglish
Pages (from-to)25-27
Number of pages3
JournalEuropean Journal of Pharmacology
Volume497
Issue number1
DOIs
Publication statusPublished - Aug 16 2004

Keywords

  • Hypoxia
  • mGlu5 knockout
  • mouse
  • Reactive oxygen species

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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