Mouse models for down syndrome-associated developmental cognitive disabilities

Chunhong Liu; Pavel V. Belichenko; Li Zhang; Dawei Fu; Alexander M. Kleschevnikov; Antonio Baldini; Stylianos E. Antonarakis; William C. Mobley; Y. Eugene Yu

doi:10.1159/000329422

Mouse models for down syndrome-associated developmental cognitive disabilities

Chunhong Liu, Pavel V. Belichenko, Li Zhang, Dawei Fu, Alexander M. Kleschevnikov, Antonio Baldini, Stylianos E. Antonarakis, William C. Mobley, Y. Eugene Yu

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Research output: Contribution to journal › Article

Abstract

Down syndrome (DS) is mainly caused by the presence of an extra copy of human chromosome 21 (Hsa21) and is a leading genetic cause for developmental cognitive disabilities in humans. The mouse is a premier model organism for DS because the regions on Hsa21 are syntenically conserved with three regions in the mouse genome, which are located on mouse chromosome 10 (Mmu10), Mmu16 and Mmu17. With the advance of chromosomal manipulation technologies, new mouse mutants have been generated to mimic DS at both the genotypic and phenotypic levels. Further mouse-based molecular genetic studies in the future may lead to the unraveling of the mechanisms underlying DS-associated developmental cognitive disabilities, which would lay the groundwork for developing effective treatments for this phenotypic manifestation. In this review, we will discuss recent progress and future challenges in modeling DS-associated developmental cognitive disability in mice with an emphasis on hippocampus-related phenotypes.

Original language	English
Pages (from-to)	404-413
Number of pages	10
Journal	Developmental Neuroscience
Volume	33
Issue number	5
DOIs	https://doi.org/10.1159/000329422
Publication status	Published - Nov 2011

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Keywords

Developmental cognitive disabilities
Down syndrome
Human trisomy 21
Mouse models
Targeted chromosome manipulation

ASJC Scopus subject areas

Developmental Neuroscience
Neurology

Cite this

Liu, C., Belichenko, P. V., Zhang, L., Fu, D., Kleschevnikov, A. M., Baldini, A., Antonarakis, S. E., Mobley, W. C., & Yu, Y. E. (2011). Mouse models for down syndrome-associated developmental cognitive disabilities. Developmental Neuroscience, 33(5), 404-413. https://doi.org/10.1159/000329422

Mouse models for down syndrome-associated developmental cognitive disabilities. / Liu, Chunhong; Belichenko, Pavel V.; Zhang, Li; Fu, Dawei; Kleschevnikov, Alexander M.; Baldini, Antonio; Antonarakis, Stylianos E.; Mobley, William C.; Yu, Y. Eugene.

In: Developmental Neuroscience, Vol. 33, No. 5, 11.2011, p. 404-413.

Research output: Contribution to journal › Article

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10.1159/000329422