Mouse models of the 5-HTTLPR × stress risk factor for depression

Valeria Carola, Cornelius Gross

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The incidence of mood disorders is known to be influenced by both genetic as well as environmental factors. Increasingly, however it is becoming clear that few genetic and environmental factors act alone, but that instead they regularly act in concert to determine predisposition to psychiatric disorders. Quite a few cases now have been reported in which stratification of subjects by exposure to environmental pathogens has been shown to alter the association between specific genetic variants and mental illness. The best studied of such measured gene-by-environment risk factors for mental illness is the increased risk for major depression reported among persons carrying the short variant (S allele) of a functional polymorphism in the serotonin transporter (5-HTT, SLC6A4) gene promoter and who have been exposed to stressful life events. Recently, a large number of laboratories have tried to model the interaction between 5-HTTLPR genotype and early/adult stress in mouse. Findings from their studies have helped to define the rodent orthologs of the environmental stressors and behavioral traits involved in risk for depression. Furthermore, several of these studies attempted to identify changes in molecular substrates that might underlie the 5-HTT × stress risk factor, pointing to the hippocampus and frontal cortex as critical brain structures involved in the interaction between 5-HTT gene variation and early and adult stress, respectively. These results will serve to help inform clinical research into the origins of major depression and other mental illnesses with interacting genetic and environmental risk factors.

Original languageEnglish
Pages (from-to)59-72
Number of pages14
JournalCurrent Topics in Behavioral Neurosciences
Volume12
DOIs
Publication statusPublished - Feb 14 2012

Fingerprint

Depression
Genes
Serotonin Plasma Membrane Transport Proteins
Environmental Exposure
Frontal Lobe
Mood Disorders
Psychiatry
Rodentia
Hippocampus
Alleles
Genotype
Incidence
Brain
Research

Keywords

  • Anxiety-depression
  • Early/adult stress risk factor
  • Gene-by-environment
  • Mouse models
  • Serotonin transporter

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Medicine(all)

Cite this

Mouse models of the 5-HTTLPR × stress risk factor for depression. / Carola, Valeria; Gross, Cornelius.

In: Current Topics in Behavioral Neurosciences, Vol. 12, 14.02.2012, p. 59-72.

Research output: Contribution to journalArticle

Carola, Valeria ; Gross, Cornelius. / Mouse models of the 5-HTTLPR × stress risk factor for depression. In: Current Topics in Behavioral Neurosciences. 2012 ; Vol. 12. pp. 59-72.
@article{d4c135804d9a40f0b0ff6f9888c6a406,
title = "Mouse models of the 5-HTTLPR × stress risk factor for depression",
abstract = "The incidence of mood disorders is known to be influenced by both genetic as well as environmental factors. Increasingly, however it is becoming clear that few genetic and environmental factors act alone, but that instead they regularly act in concert to determine predisposition to psychiatric disorders. Quite a few cases now have been reported in which stratification of subjects by exposure to environmental pathogens has been shown to alter the association between specific genetic variants and mental illness. The best studied of such measured gene-by-environment risk factors for mental illness is the increased risk for major depression reported among persons carrying the short variant (S allele) of a functional polymorphism in the serotonin transporter (5-HTT, SLC6A4) gene promoter and who have been exposed to stressful life events. Recently, a large number of laboratories have tried to model the interaction between 5-HTTLPR genotype and early/adult stress in mouse. Findings from their studies have helped to define the rodent orthologs of the environmental stressors and behavioral traits involved in risk for depression. Furthermore, several of these studies attempted to identify changes in molecular substrates that might underlie the 5-HTT × stress risk factor, pointing to the hippocampus and frontal cortex as critical brain structures involved in the interaction between 5-HTT gene variation and early and adult stress, respectively. These results will serve to help inform clinical research into the origins of major depression and other mental illnesses with interacting genetic and environmental risk factors.",
keywords = "Anxiety-depression, Early/adult stress risk factor, Gene-by-environment, Mouse models, Serotonin transporter",
author = "Valeria Carola and Cornelius Gross",
year = "2012",
month = "2",
day = "14",
doi = "10.1007/7854_2011_190",
language = "English",
volume = "12",
pages = "59--72",
journal = "Current Topics in Behavioral Neurosciences",
issn = "1866-3370",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - Mouse models of the 5-HTTLPR × stress risk factor for depression

AU - Carola, Valeria

AU - Gross, Cornelius

PY - 2012/2/14

Y1 - 2012/2/14

N2 - The incidence of mood disorders is known to be influenced by both genetic as well as environmental factors. Increasingly, however it is becoming clear that few genetic and environmental factors act alone, but that instead they regularly act in concert to determine predisposition to psychiatric disorders. Quite a few cases now have been reported in which stratification of subjects by exposure to environmental pathogens has been shown to alter the association between specific genetic variants and mental illness. The best studied of such measured gene-by-environment risk factors for mental illness is the increased risk for major depression reported among persons carrying the short variant (S allele) of a functional polymorphism in the serotonin transporter (5-HTT, SLC6A4) gene promoter and who have been exposed to stressful life events. Recently, a large number of laboratories have tried to model the interaction between 5-HTTLPR genotype and early/adult stress in mouse. Findings from their studies have helped to define the rodent orthologs of the environmental stressors and behavioral traits involved in risk for depression. Furthermore, several of these studies attempted to identify changes in molecular substrates that might underlie the 5-HTT × stress risk factor, pointing to the hippocampus and frontal cortex as critical brain structures involved in the interaction between 5-HTT gene variation and early and adult stress, respectively. These results will serve to help inform clinical research into the origins of major depression and other mental illnesses with interacting genetic and environmental risk factors.

AB - The incidence of mood disorders is known to be influenced by both genetic as well as environmental factors. Increasingly, however it is becoming clear that few genetic and environmental factors act alone, but that instead they regularly act in concert to determine predisposition to psychiatric disorders. Quite a few cases now have been reported in which stratification of subjects by exposure to environmental pathogens has been shown to alter the association between specific genetic variants and mental illness. The best studied of such measured gene-by-environment risk factors for mental illness is the increased risk for major depression reported among persons carrying the short variant (S allele) of a functional polymorphism in the serotonin transporter (5-HTT, SLC6A4) gene promoter and who have been exposed to stressful life events. Recently, a large number of laboratories have tried to model the interaction between 5-HTTLPR genotype and early/adult stress in mouse. Findings from their studies have helped to define the rodent orthologs of the environmental stressors and behavioral traits involved in risk for depression. Furthermore, several of these studies attempted to identify changes in molecular substrates that might underlie the 5-HTT × stress risk factor, pointing to the hippocampus and frontal cortex as critical brain structures involved in the interaction between 5-HTT gene variation and early and adult stress, respectively. These results will serve to help inform clinical research into the origins of major depression and other mental illnesses with interacting genetic and environmental risk factors.

KW - Anxiety-depression

KW - Early/adult stress risk factor

KW - Gene-by-environment

KW - Mouse models

KW - Serotonin transporter

UR - http://www.scopus.com/inward/record.url?scp=84878362923&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878362923&partnerID=8YFLogxK

U2 - 10.1007/7854_2011_190

DO - 10.1007/7854_2011_190

M3 - Article

C2 - 22331694

AN - SCOPUS:84878362923

VL - 12

SP - 59

EP - 72

JO - Current Topics in Behavioral Neurosciences

JF - Current Topics in Behavioral Neurosciences

SN - 1866-3370

ER -