Movement disorders in a twins pair

A casual expression or genetic determination?

Leonarda Gennaro, Luigi Russo, Luciana Losito, Alessia Zaccaria, Marta De Rinaldis, Antonio Trabacca

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A twin study is an excellent means of assessing the contribution of heritability to motor behaviour. We present a movement video-analysis of a monozygotic twins pair with a motor repertoire which is almost totally constituted by persistent and subcontinuous motor stereotypies. Purpose: The specific aim of this study is to verify the heritable quantum of motor behaviour and to determine which among the motor patterns we analysed are more likely to be conditioned by inheritance. Methods: Stereotyped movements were videotaped in two standardized sessions: at rest and in relation to preordained sensory stimulations. We estimated the concordance index (CI) between the observers to evaluate the reliability of the observations. The validity was accepted as being CI > 0.80. Results: The results showed a very high concordance rate (>90%) for all the stereotypies analysed. An almost superimposable trend of the stereotyped movements was found both at rest and in relation to the sensory stimulations. Conclusions: Such strong data suggest that genetic factors have a primary influence on all the movement disorders analysed. This study contributes to a better understanding of the complex relationships between genes and functions.

Original languageEnglish
Pages (from-to)692-697
Number of pages6
JournalResearch in Developmental Disabilities
Volume31
Issue number3
DOIs
Publication statusPublished - May 2010

Fingerprint

Twin Studies
Monozygotic Twins
Movement Disorders
Genes

Keywords

  • Children
  • Heritability
  • Mental retardation
  • Movement disorders
  • Stereotypy
  • Twin method

ASJC Scopus subject areas

  • Clinical Psychology
  • Developmental and Educational Psychology

Cite this

Movement disorders in a twins pair : A casual expression or genetic determination? / Gennaro, Leonarda; Russo, Luigi; Losito, Luciana; Zaccaria, Alessia; De Rinaldis, Marta; Trabacca, Antonio.

In: Research in Developmental Disabilities, Vol. 31, No. 3, 05.2010, p. 692-697.

Research output: Contribution to journalArticle

Gennaro, Leonarda ; Russo, Luigi ; Losito, Luciana ; Zaccaria, Alessia ; De Rinaldis, Marta ; Trabacca, Antonio. / Movement disorders in a twins pair : A casual expression or genetic determination?. In: Research in Developmental Disabilities. 2010 ; Vol. 31, No. 3. pp. 692-697.
@article{47c635cc56a7487cb86d873ef810f75a,
title = "Movement disorders in a twins pair: A casual expression or genetic determination?",
abstract = "A twin study is an excellent means of assessing the contribution of heritability to motor behaviour. We present a movement video-analysis of a monozygotic twins pair with a motor repertoire which is almost totally constituted by persistent and subcontinuous motor stereotypies. Purpose: The specific aim of this study is to verify the heritable quantum of motor behaviour and to determine which among the motor patterns we analysed are more likely to be conditioned by inheritance. Methods: Stereotyped movements were videotaped in two standardized sessions: at rest and in relation to preordained sensory stimulations. We estimated the concordance index (CI) between the observers to evaluate the reliability of the observations. The validity was accepted as being CI > 0.80. Results: The results showed a very high concordance rate (>90{\%}) for all the stereotypies analysed. An almost superimposable trend of the stereotyped movements was found both at rest and in relation to the sensory stimulations. Conclusions: Such strong data suggest that genetic factors have a primary influence on all the movement disorders analysed. This study contributes to a better understanding of the complex relationships between genes and functions.",
keywords = "Children, Heritability, Mental retardation, Movement disorders, Stereotypy, Twin method",
author = "Leonarda Gennaro and Luigi Russo and Luciana Losito and Alessia Zaccaria and {De Rinaldis}, Marta and Antonio Trabacca",
year = "2010",
month = "5",
doi = "10.1016/j.ridd.2010.01.009",
language = "English",
volume = "31",
pages = "692--697",
journal = "Research in Developmental Disabilities",
issn = "0891-4222",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Movement disorders in a twins pair

T2 - A casual expression or genetic determination?

AU - Gennaro, Leonarda

AU - Russo, Luigi

AU - Losito, Luciana

AU - Zaccaria, Alessia

AU - De Rinaldis, Marta

AU - Trabacca, Antonio

PY - 2010/5

Y1 - 2010/5

N2 - A twin study is an excellent means of assessing the contribution of heritability to motor behaviour. We present a movement video-analysis of a monozygotic twins pair with a motor repertoire which is almost totally constituted by persistent and subcontinuous motor stereotypies. Purpose: The specific aim of this study is to verify the heritable quantum of motor behaviour and to determine which among the motor patterns we analysed are more likely to be conditioned by inheritance. Methods: Stereotyped movements were videotaped in two standardized sessions: at rest and in relation to preordained sensory stimulations. We estimated the concordance index (CI) between the observers to evaluate the reliability of the observations. The validity was accepted as being CI > 0.80. Results: The results showed a very high concordance rate (>90%) for all the stereotypies analysed. An almost superimposable trend of the stereotyped movements was found both at rest and in relation to the sensory stimulations. Conclusions: Such strong data suggest that genetic factors have a primary influence on all the movement disorders analysed. This study contributes to a better understanding of the complex relationships between genes and functions.

AB - A twin study is an excellent means of assessing the contribution of heritability to motor behaviour. We present a movement video-analysis of a monozygotic twins pair with a motor repertoire which is almost totally constituted by persistent and subcontinuous motor stereotypies. Purpose: The specific aim of this study is to verify the heritable quantum of motor behaviour and to determine which among the motor patterns we analysed are more likely to be conditioned by inheritance. Methods: Stereotyped movements were videotaped in two standardized sessions: at rest and in relation to preordained sensory stimulations. We estimated the concordance index (CI) between the observers to evaluate the reliability of the observations. The validity was accepted as being CI > 0.80. Results: The results showed a very high concordance rate (>90%) for all the stereotypies analysed. An almost superimposable trend of the stereotyped movements was found both at rest and in relation to the sensory stimulations. Conclusions: Such strong data suggest that genetic factors have a primary influence on all the movement disorders analysed. This study contributes to a better understanding of the complex relationships between genes and functions.

KW - Children

KW - Heritability

KW - Mental retardation

KW - Movement disorders

KW - Stereotypy

KW - Twin method

UR - http://www.scopus.com/inward/record.url?scp=77950669890&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950669890&partnerID=8YFLogxK

U2 - 10.1016/j.ridd.2010.01.009

DO - 10.1016/j.ridd.2010.01.009

M3 - Article

VL - 31

SP - 692

EP - 697

JO - Research in Developmental Disabilities

JF - Research in Developmental Disabilities

SN - 0891-4222

IS - 3

ER -