Movement-related electroencephalographic reactivity in Alzheimer Disease

C. Babiloni, F. Babiloni, F. Carducci, F. Cincotti, C. Del Percio, G. De Pino, S. Maestrini, A. Priori, P. Tisei, O. Zanetti, P. M. Rossini

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Event-related desynchronization/synchronization (ERD/ERS) of alpha and beta electroencephalographic (EEG) rhythms was investigated in normal subjects and mild Alzheimer Disease patients (AD), performing unilateral right finger movements (about 10 s intermovement interval). Electroencephalographic data were sampled based on 10-20 system electrode montage. Surface Laplacian estimate of the potential reduced the head-volume conductor effects and annulled electrode reference variations. Results showed that EEG reactivity (i.e., ERD/ERS) of modeled contralateral rolandic cortex and motor performance were preserved in mild to moderate AD. In contrast, modeled activity (i.e., ERD/ERS) of frontolateral, centromedial, and ipsilateral rolandic areas was abnormal. Furthermore, interrelatedness of cortical response and movement timing was abnormal in AD patients. These results would support the working hypothesis that mild to moderate AD is a global brain network disease, including processing of sensorimotor information (despite no overt movement disorder). Further investigations will ascertain the clinical relevance of these results. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)139-146
Number of pages8
JournalNeuroImage
Volume12
Issue number2
DOIs
Publication statusPublished - 2000

Fingerprint

Alzheimer Disease
Electrodes
Beta Rhythm
Movement Disorders
Motor Cortex
Brain Diseases
Automatic Data Processing
Fingers
Head

Keywords

  • Aging
  • Alpha rhythm
  • Beta rhythm
  • Cerebral cortex
  • Motor control
  • Voluntary movements

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Movement-related electroencephalographic reactivity in Alzheimer Disease. / Babiloni, C.; Babiloni, F.; Carducci, F.; Cincotti, F.; Del Percio, C.; De Pino, G.; Maestrini, S.; Priori, A.; Tisei, P.; Zanetti, O.; Rossini, P. M.

In: NeuroImage, Vol. 12, No. 2, 2000, p. 139-146.

Research output: Contribution to journalArticle

Babiloni, C, Babiloni, F, Carducci, F, Cincotti, F, Del Percio, C, De Pino, G, Maestrini, S, Priori, A, Tisei, P, Zanetti, O & Rossini, PM 2000, 'Movement-related electroencephalographic reactivity in Alzheimer Disease', NeuroImage, vol. 12, no. 2, pp. 139-146. https://doi.org/10.1006/nimg.2000.0602
Babiloni, C. ; Babiloni, F. ; Carducci, F. ; Cincotti, F. ; Del Percio, C. ; De Pino, G. ; Maestrini, S. ; Priori, A. ; Tisei, P. ; Zanetti, O. ; Rossini, P. M. / Movement-related electroencephalographic reactivity in Alzheimer Disease. In: NeuroImage. 2000 ; Vol. 12, No. 2. pp. 139-146.
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