Movement-related modulation of neural activity in human basal ganglia and its L-DOPA dependency: Recordings from deep brain stimulation electrodes in patients with Parkinson's disease

A. Priori, G. Foffani, A. Pesenti, A. Bianchi, V. Chiesa, G. Baselli, E. Caputo, F. Tamma, P. Rampini, M. Egidi, M. Locatelli, S. Barbieri, G. Scarlato

Research output: Contribution to journalArticle

Abstract

Through electrodes implanted for deep brain stimulation in three patients (5 sides) with Parkinson's disease, we recorded the electrical activity from the human basal ganglia before, during and after voluntary contralateral finger movements, before and after L-DOPA. We analysed the movement-related spectral changes in the electro-encephalographic signal from the subthalamic nucleus (STN) and from the internal globus pallidus (GPi). Before, during and after voluntary movements, signals arising from the human basal ganglia contained two main frequencies: a high β (around 26 Hz), and a low β (around 18 Hz). The high β (around 26 Hz) power decreased in the STN and GPi, whereas the low β (around 18 Hz) power decrease was consistently found only in the GPi. Both frequencies changed their power with a specific temporal modulation related to the different movement phases. L-DOPA specifically and selectively influenced the spectral power changes in these two signal bands.

Original languageEnglish
JournalNeurological Sciences
Volume23
Issue numberSUPPL. 2
DOIs
Publication statusPublished - Sep 2002

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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