Movement symptoms in European Moyamoya angiopathy — First systematic questionnaire study

Markus Kraemer, Leonidas Trakolis, Jens Platzen, Jan Claudius Schwitalla, Anna Bersano, Philipp Albrecht, Marc Schlamann, Peter Berlit

Research output: Contribution to journalArticle

Abstract

Objective Movement disorders are a rare manifestation of Moyamoya angiopathy (MMA). Data on prevalence and clinical presentation are warranted. Possible involuntary movements include focal motor seizures, tremor, limb-shaking transient ischemic attacks, choreiform and spastic or dystonic movement disorders. Patients and methods We developed a questionnaire to systematically assess movement disorders in MMA. Patients’ history of involuntary movements and their clinical presentation were assessed systematically by interview. Additionally, demographic data were assessed as well as localization of movements, possible trigger factors and the presence of other symptoms. Results The questionnaire was administered to 63 European patients with MMA. The response rate was high with 93.6% participating patients. Twenty-eight patients (47.4%) reported involuntary movement disorders including periodic tremor, irregular jerks, involuntary movements with loopy or pranced character, stiffness and muscle cramps. From those patients, 16 (57.1%) individuals had the symptoms prior to the diagnosis of MMA. The most common involuntary movements were irregular jerks witnessed by 17 (60.7%) patients, followed by stiffness and muscle cramps in 10 (35.7%). Eight (28.6%) Patients suffered from unintended loopy and pranced character, while 4 individuals (14.3%) remembered periodic tremor. Of the 28 patients who witnessed movement disorders, 23 had undergone revascularization surgery (82.1%). From the latter subgroup, movement disorders were reversed in 7 out of 12 patients (58.3%) with irregular jerks and 4 out of 7 patients (57.1%) with unintended loopy and pranced character. Conclusions Our study elucidates the high incidence of movement disorders in an unselected consecutively recruited cohort of European MMA patients.

Original languageEnglish
Pages (from-to)52-56
Number of pages5
JournalClinical Neurology and Neurosurgery
Volume152
DOIs
Publication statusPublished - Jan 1 2017

Keywords

  • Choreiform and spastic or dystonic movement disorders
  • Focal motor seizures
  • Limb-shaking transient ischemic attacks
  • Movement symptoms
  • Moyamoya angiopathy
  • Tremor

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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    Kraemer, M., Trakolis, L., Platzen, J., Schwitalla, J. C., Bersano, A., Albrecht, P., Schlamann, M., & Berlit, P. (2017). Movement symptoms in European Moyamoya angiopathy — First systematic questionnaire study. Clinical Neurology and Neurosurgery, 152, 52-56. https://doi.org/10.1016/j.clineuro.2016.11.017